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Literature summary for 3.4.15.1 extracted from
- Angiotensin-converting enzyme and the regulation of vasoactive peptides (1976), Annu. Rev. Biochem., 45, 73-94.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetyl-Ala-Ala-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus |  |
| Acetyl-Ala-Ala-Ala-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Ala-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Ala-Ala | - |
Sus scrofa | |
| Ala-Ala-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Ala-Ala-Ala-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| angiotensin II | - |
Cavia porcellus | |
| angiotensin II | - |
Homo sapiens | |
| angiotensin II | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| angiotensin II | - |
Sus scrofa | |
| Arg-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Arg-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Asp-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| His-Leu | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| His-Leu | - |
Sus scrofa | |
| Leu-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Lys-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Phe-Arg | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Asn-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Asn-Trp-Pro-His-Pro-Gln-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Gly-Gly-Trp-Pro-Arg-Pro-Gly-Pro-Glu-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Gly-Leu-Pro-Pro-Arg-Pro-Lys-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Gly-Leu-Pro-Pro-Gly-Pro-Pro-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Lys-Trp-Ala-Pro | i.e. venom bradykinin-potentiating peptide V-3A, hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Ser-Trp-Pro-Asn-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Pyr-Trp-Pro-Arg-Pro-Thr-Pro-Gln-Ile-Pro-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Ser-Pro | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
| Tyr-Ala | hydrolysis of hippuryl-His-Leu | Oryctolagus cuniculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
angiotensin I | - |
Oryctolagus cuniculus | |
| 2.3 | - |
hippuryl-Lys-Leu | - |
Oryctolagus cuniculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | - |
Homo sapiens | |
| Zinc | contains approximately one molar equivalent of bound zinc | Oryctolagus cuniculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 129000 | - |
equilibrium sedimentation | Oryctolagus cuniculus |
| 136000 | - |
glycerol density gradient centrifugation | Oryctolagus cuniculus |
| 140000 | - |
x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| side-chain modification | glycoprotein | Cavia porcellus |
| side-chain modification | glycoprotein | Homo sapiens |
| side-chain modification | glycoprotein | Sus scrofa |
| side-chain modification | glycoprotein | Oryctolagus cuniculus |
| side-chain modification | oligosaccharide accounts for 26% of the weight | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Cavia porcellus | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Sus scrofa | - |
| lung | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| angiotensin I + H2O | - |
Cavia porcellus | angiotensin II + His-Leu | - |
? | |
| angiotensin I + H2O | - |
Homo sapiens | angiotensin II + His-Leu | - |
? | |
| angiotensin I + H2O | - |
Sus scrofa | angiotensin II + His-Leu | - |
? | |
| angiotensin I + H2O | about 5% of the activity with hippury-Lys-Leu | Oryctolagus cuniculus | angiotensin II + His-Leu | - |
? | |
| bradykinin + H2O | - |
Cavia porcellus | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
| bradykinin + H2O | - |
Homo sapiens | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
| bradykinin + H2O | - |
Sus scrofa | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
| bradykinin + H2O | about 3.5% of the activity with hippury-Lys-Leu | Oryctolagus cuniculus | Phe-Arg + Ser-Pro + Arg-Pro-Pro-Gly-Phe | - |
? | |
| hippuryl-Lys-Leu + H2O | - |
Oryctolagus cuniculus | hippuric acid + Lys-Leu | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Homo sapiens |
| ? | - |
Sus scrofa |
| ? | x * 140000, enzyme from lung, SDS-PAGE with 7% acryl amide | Oryctolagus cuniculus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 9.1 | - |
bradykinin | - |
Oryctolagus cuniculus | |
| 13.2 | - |
angiotensin I | - |
Oryctolagus cuniculus | |
| 257 | - |
hippuryl-His-Leu | - |
Oryctolagus cuniculus | |
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