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Literature summary for 3.4.15.1 extracted from

  • Rutkowska-Zapala, M.; Suski, M.; Szatanek, R.; Lenart, M.; Weglarczyk, K.; Olszanecki, R.; Grodzicki, T.; Strach, M.; Gasowski, J.; Siedlar, M.
    Human monocyte subsets exhibit divergent angiotensin I-converting activity (2015), Clin. Exp. Immunol., 181, 126-132 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.15.1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Homo sapiens
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P12821
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood vessel
-
 Homo sapiens
-
monocyte classical, CD14++CD16- cells Homo sapiens
-
additional information highest relative level of ACE1 mRNA expression is observed in CD14++CD16- (classical) monocytes. In peripheral blood mononuclear cells (PBMC), monocytes and classical monocytes, ACE1 protein expression is stronger compared to other monocyte subpopulations. ACE1 expression is slightly more diverse than ACE2 (EC 3.4.17.23) levels, imune cell expression analysis Homo sapiens
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peripheral blood mononuclear cell PBMC Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Homo sapiens angiotensin II + L-His-L-Leu
-
 ?

Synonyms

Synonyms Comment Organism
ACEI
-
 Homo sapiens
angiotensin-converting enzyme type 1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview Homo sapiens
physiological function the enzyme is involved in the renin-angiotensin system (RAS), which includes angiotensin I, angiotensin (Ang)II, and peptides angiotensin-(1-9) and angiotensin-(1-7) derived by C-terminal cleavage of their particular antecessors by angiotensin converting enzyme (ACE)1 or ACE2, overview. Because of intensive local formation, the actions of nonclassical angiotensins could be especially important in the paracrine regulation of tissue physiology. RAAS may play a role in the regulation of blood pressure not only in a systemic endocrine manner, but also by local actions of various angiotensins (renin-angiotensin system, RAS) on vessel wall homeostasis Homo sapiens