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Literature summary for 3.4.15.1 extracted from

  • Ye, M.; Wysocki, J.; Gonzalez-Pacheco, F.R.; Salem, M.; Evora, K.; Garcia-Halpin, L.; Poglitsch, M.; Schuster, M.; Batlle, D.
    Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2 (2012), Hypertension, 60, 730-740.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed as a His-tagged fusion protein in 293F cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
MLN-4760 conversion of Ang II to Ang(1-7) is blocked by MLN-4760 but not by DX600 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 species differences regarding rodent and human ACE2 in terms of substrate specificity and inhibitors
-

Purification (Commentary)

Purification (Comment) Organism
using affinity chromatography and gel filtration Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O converts Ang II to Ang(1-7) Mus musculus ?
-
 ?
Mca-APK-Dnp + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE2
-
 Mus musculus

General Information

General Information Comment Organism
physiological function mouse ACE2 (1 mg/kg) obliterates hypertension induced by Ang II infusion by rapidly decreasing plasma Ang II Mus musculus