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Literature summary for 3.4.15.1 extracted from

  • Levy, P.D.; Nandyal, D.; Welch, R.D.; Sun, J.L.; Pieper, K.; Ghali, J.K.; Fonarow, G.C.; Gheorgiade, M.; OConnor, C.M.
    Does aspirin use adversely influence intermediate-term postdischarge outcomes for hospitalized patients who are treated with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers? Organized Program to Facilitate Life-Saving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) (2010), Am. Heart J., 159, 222-230.e2.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme inhibition, leading to bradykinin potentiation, is a therapeutic strategy in heart failure for bradykinin-induced systemic arterial vasodilatation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the enzyme inhibition by angiotensin-converting enzyme inhibitors is inhibited by aspirin, which can cause therapeutic problems during application of both in treatment of heart failure patients. Angiotensin receptor blockers do not interfere with the bradykinin pathway, detailed overview Homo sapiens
warfarin
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
bradykinin + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bradykinin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ACE
-
Homo sapiens
angiotensin-converting enzyme
-
Homo sapiens

General Information

General Information Comment Organism
additional information the enzyme inhibition by angiotensin-converting enzyme inhibitors is inhibited by aspirin, which can cause therapeutic problems during application of both in treatment of heart failure patients. Angiotensin receptor blockers do not interfere with the bradykinin pathway, detailed overview Homo sapiens