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Literature summary for 3.4.15.1 extracted from

  • Hyun, S.K.; Lee, H.; Kang, S.S.; Chung, H.Y.; Choi, J.S.
    Inhibitory activities of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme (2009), Phytother. Res., 23, 178-184.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
2-hydroxyemodin 1-methylether 47.52% inhibition at 1.63 ng/ml Oryctolagus cuniculus
alaternin 24.26% inhibition at 1.63 ng/ml Oryctolagus cuniculus
captopril 87.87% inhibition at 1.63 ng/ml Oryctolagus cuniculus
emodin 45.79% inhibition at 1.63 ng/ml Oryctolagus cuniculus
gluco-aurantioobtusin competitive inhibitor, 137.62% inhibition at 1.63 ng/ml Oryctolagus cuniculus
additional information ACE is not inhibited by gluco-obtusifolin, obtusifolin, aurantioobtusin, cassitoroside, toralactone gentiobioside, chrysophanol triglucoside, questin, and cassiaside; both of the methanol extracts from the raw and roasted Cassia tora seeds exhibit significant inhibitory properties against ACE, demonstrating more than 50% inhibition at a concentration of 0.16393 mg/ml Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Oryctolagus cuniculus
-
 angiotensin II + L-His-L-Leu
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Oryctolagus cuniculus angiotensin II + L-His-L-Leu
-
 ?
N-[3-(2-furyl)acryloyl]-L-Phe-Gly-Gly + H2O
-
 Oryctolagus cuniculus 2-furylacrylic acid + L-Phe-Gly-Gly
-
 ?

Synonyms

Synonyms Comment Organism
ACE
-
 Oryctolagus cuniculus
angiotensin-converting enzyme
-
 Oryctolagus cuniculus
peptidyldipeptide hydrolase
-
 Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000083
-
 gluco-aurantioobtusin in 50 mM Tris-HCl buffer (pH 7.5) Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03024
-
 in 50 mM Tris-HCl buffer (pH 7.5) Oryctolagus cuniculus gluco-aurantioobtusin