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Literature summary for 3.4.15.1 extracted from

  • Ren, J.; Li, H.; Prior, B.M.; Yang, H.T.
    Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion (2008), Am. J. Med. Sci., 335, 177-187.
    View publication on PubMed
Search for more literature for 3.4.15.1

Application

Application Comment Organism
medicine ACE inhibition is a therapeutic target in treating peripheral occlusive arterial disease Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
quinapril 18 mg/kg quinapril per day feeding for 3 days significantly reduces blood plasma ACE activity by 80%, quinapril administration for 16 days greatly decreases blood plasma ACE activity by 88% with 18 mg/kg per day, ACE activities in the heart, lung, and skeletal muscles of the 16-day ACE-inhibition with 18 mg/kg per day are 9%, 16%, and 22% of the controls, respectively Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Rattus norvegicus
-
 angiotensin II + L-His-L-Leu
-
 ?
bradykinin + H2O Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-
skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Rattus norvegicus angiotensin II + L-His-L-Leu
-
 ?
bradykinin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
ACE
-
 Rattus norvegicus
angiotensin converting enzyme
-
 Rattus norvegicus
DCP
-
 Rattus norvegicus