Literature summary for 3.4.15.1 extracted from

Lefebvre, H.P.; Brown, S.A.; Chetboul, V.; King, J.N.; Pouchelon, J.L.; Toutain, P.L.
Angiotensin-converting enzyme inhibitors in veterinary medicine (2007), Curr. Pharm. Des., 13, 1347-1361.

Search for more literature for 3.4.15.1

Application

Application	Comment	Organism
veterinary medicine	angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions	Canis lupus familiaris
veterinary medicine	angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions	Felis catus

Inhibitors

Inhibitors	Comment	Organism	Structure
benazeprilat	-	Canis lupus familiaris
benazeprilat	-	Felis catus
enalaprilat	-	Canis lupus familiaris
imidaprilat	-	Canis lupus familiaris
additional information	angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions	Canis lupus familiaris
additional information	angiotensin-converting enzyme inhibitors are recommended in dogs and cats with chronic renal failure. They decrease the glomerular capillary pressure, have antiproteinuric effects, tend to delay the progression of chronic renal failure and to limit the extent of renal lesions	Felis catus
ramiprilat	-	Canis lupus familiaris

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-
Felis catus	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00000028	-	-	Canis lupus familiaris	benazeprilat
0.0000004	-	-	Canis lupus familiaris	ramiprilat
0.00000053	0.00000081	-	Felis catus	benazeprilat
0.00000109	-	-	Canis lupus familiaris	enalaprilat
0.00000278	-	-	Canis lupus familiaris	imidaprilat

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Release 2023.1 (January 2023)