Protein Variants | Comment | Organism |
---|---|---|
S730A | cleavage secretion of the mutant angiotensin-converting enzyme remains susceptible to the enhancing effect of phorbol 12-myristate 13-acetate and calmodulin inhibitor CaMI | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Oryctolagus cuniculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
expressed in a mouse epithelial cell line or in HeLa cells permanently transfected with gACE expression vector | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | tyrosine phosphorylation of the ectodomain of ACE regulates the cleavage secretion of the enzymatically active ectodomain of angiotensin-converting enzyme. ACE is also phosphorylated at Ser730 of the cytoplasmic domain. Phorbol 12-myristate 13-acetate and calmodulin inhibitor CaMI can enhance both cleavage secretion of ACE and its dephosphorylation | Oryctolagus cuniculus |
Purification (Comment) | Organism |
---|---|
- |
Oryctolagus cuniculus |