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Literature summary for 3.4.15.1 extracted from

  • Kawamura, T.; Kikuno, K.; Oda, T.; Muramatsu, T.
    Some molecular and inhibitory specifications of a dipeptidyl carboxypeptidase from the polychaete Neanthes virens resembling angiotensin I converting enzyme (2000), Biosci. Biotechnol. Biochem., 64, 2193-2200.
    View publication on PubMed
Search for more literature for 3.4.15.1

Inhibitors

Inhibitors Comment Organism Structure
1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluene sulfonate 20 mM, 99.6% inhibition Alitta virens
2,3-butendione 10 mM, 97.4% inhibition Alitta virens
Arg-Phe IC50: 4.365 mM Alitta virens
chloramine-T 50 mM, 97.1% inhibition Alitta virens
diethyl dicarbonate 10 mM, 92.8% inhibition Alitta virens
Gly-Phe IC50: 10.471 mM Alitta virens
Gly-Trp IC50: 20.417 mM Alitta virens
Gly-Tyr IC50: 5.495 mM Alitta virens
N-bromosuccinimide 2 mM, 99.8% inhibition Alitta virens
Phe-Gly IC50: 134.9 mM Alitta virens
Tetranitromethane 5 mM, 99.1% inhibition Alitta virens
Val-Trp IC50: 3.311 mM Alitta virens
Val-Tyr IC50: 0.263 mM Alitta virens

Organism

Organism UniProt Comment Textmining
Alitta virens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein oligosaccharide content is 8% of the weight Alitta virens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hippuryl-His-Leu + H2O
-
 Alitta virens hippuric acid + His-Leu
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.138
-
 Val-Trp pH 8.3, 37°C Alitta virens
0.203
-
 Val-Tyr pH 8.3, 37°C Alitta virens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.263
-
 IC50: 0.263 mM Alitta virens Val-Tyr
3.311
-
 IC50: 3.311 mM Alitta virens Val-Trp
4.365
-
 IC50: 4.365 mM Alitta virens Arg-Phe
5.495
-
 IC50: 5.495 mM Alitta virens Gly-Tyr
10.471
-
 IC50: 10.471 mM Alitta virens Gly-Phe
20.417
-
 IC50: 20.417 mM Alitta virens Gly-Trp
134.9
-
 IC50: 134.9 mM Alitta virens Phe-Gly