Application | Comment | Organism |
---|---|---|
medicine | dipeptidyl peptidase IV might be responsible for the shallow implantation of the placenta due to its inhibition of the invading ability of extravillous trophoblasts, causing preeclampsia at later stage of pregnancy | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27487 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JAR cell | - |
Homo sapiens | - |
trophoblast | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
DPP4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Dipeptidyl peptidase IV expression level and activity is significantly increased by small activating RNA in JAR cells. Specific inhibitor diprotin A inhibits its activity at both basal and activated levels. Dipeptidyl peptidase IV does not regulate matrix metalloprotease MMP-9 expression but represses MMP-9 activity. The invading ability of JAR cells is reduced by by small activating RNA but increased by diprotin A | Homo sapiens |