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Literature summary for 3.4.14.5 extracted from

  • Li, Y.; Li, Z.; Zhang, J.
    Dipeptidyl peptidase IV reduces trophoblast invasion by inhibiting the activity of MMPs (2014), Int. J. Dev. Biol., 58, 349-353.
    View publication on PubMed

Application

Application Comment Organism
medicine dipeptidyl peptidase IV might be responsible for the shallow implantation of the placenta due to its inhibition of the invading ability of extravillous trophoblasts, causing preeclampsia at later stage of pregnancy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27487
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-

Source Tissue

Source Tissue Comment Organism Textmining
JAR cell
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Homo sapiens
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trophoblast
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Homo sapiens
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Synonyms

Synonyms Comment Organism
DPP4
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Homo sapiens

General Information

General Information Comment Organism
physiological function Dipeptidyl peptidase IV expression level and activity is significantly increased by small activating RNA in JAR cells. Specific inhibitor diprotin A inhibits its activity at both basal and activated levels. Dipeptidyl peptidase IV does not regulate matrix metalloprotease MMP-9 expression but represses MMP-9 activity. The invading ability of JAR cells is reduced by by small activating RNA but increased by diprotin A Homo sapiens