Crystallization (Comment) | Organism |
---|---|
molecular docking simulaion for compounds ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate and ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate | compound exhibits high selectivities against dipeptidyl peptidases FAP, DPP 7, DPP 8, and DPP 9, with inhibition rates <50% at 20 microg/ml | Homo sapiens | |
ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate | compound exhibits high selectivities against dipeptidyl peptidases FAP, DPP 7, DPP 8, and DPP 9, with inhibition rates <50% at 20 microg/ml | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27487 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Ala-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | L-Ala-L-Pro + 7-amino-4-methylcoumarin | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00456 | - |
pH 7.5, temperature not specified in the publication | Homo sapiens | ethyl-2-(4-(((S)-1-((S)-2-amino-(4-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate | |
0.0084 | - |
pH 7.5, temperature not specified in the publication | Homo sapiens | ethyl-2-(4-(((S)-1-((S)-2-amino-3-(2-fluorophenyl)propanoyl)pyrrolidine-2-carboxamido)-methyl)phenoxy)acetate |