Literature summary for 3.4.14.5 extracted from

Wu, W.; Liu, Y.; Milo, L.J.; Shu, Y.; Zhao, P.; Li, Y.; Woznica, I.; Yu, G.; Sanford, D.G.; Zhou, Y.; Poplawski, S.E.; Connolly, B.A.; Sudmeier, J.L.; Bachovchin, W.W.; Lai, J.H.
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities (2012), Bioorg. Med. Chem. Lett., 22, 5536-5540.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2R,4R)-2-(dihydroxyboranyl)-4-hydroxypyrrolidin-1-yl (4S)-4-hydroxy-L-prolinate	best selectivity for dipeptidyl peptidase IV over dipeptidyl peptidases DPP8 and DPP9	Homo sapiens
[(2R,4R)-1-(L-arginyl)-4-hydroxypyrrolidin-2-yl]boronic acid	most potent inhibitor tested	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Ala-L-Pro 4-nitroanilide + H2O	-	Homo sapiens	L-Ala-L-Pro + 4-nitroaniline	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000003	-	pH 7.8, temperature not specified in the publication	Homo sapiens	[(2R,4R)-1-(L-arginyl)-4-hydroxypyrrolidin-2-yl]boronic acid
0.000016	-	pH 7.8, temperature not specified in the publication	Homo sapiens	(2R,4R)-2-(dihydroxyboranyl)-4-hydroxypyrrolidin-1-yl (4S)-4-hydroxy-L-prolinate

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Release 2023.1 (January 2023)