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Literature summary for 3.4.14.5 extracted from

  • Merchant, M.; Mead, S.; McAdon, C.; McFatter, J.; Wasilewski, J.
    Identification and characterization of dipeptidyl peptidase IV enzyme activity in the American crocodile (Crocodylus acutus) (2010), Vet. Immunol. Immunopathol., 136, 28-33.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
Diprotin A specific inhibitor of DPP4 activity, diprotin A is L-Leu–L-Pro-L-Leu, coincubation of a 0.5, 1, 2, 5, and 10fold concentration of diprotin A (relative to the L-Ala-L-Pro-7-amido-4-trifluoromethylcoumarin substrate concentration) results in 52, 71, 77, 86, and 89% reduction in DPP4 activity, respectively Crocodylus acutus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0147
-
 L-Ala-L-Pro-7-amido-4-trifluoromethylcoumarin in 100 mM Tris-HCl, pH 7.4 Crocodylus acutus

Organism

Organism UniProt Comment Textmining
Crocodylus acutus
-
 American crocodile
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Crocodylus acutus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Ala-L-Pro-7-amido-4-trifluoromethylcoumarin + H2O
-
 Crocodylus acutus L-Ala-L-Pro + 7-amino-4-trifluoromethylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Crocodylus acutus
dipeptidyl peptidase IV
-
 Crocodylus acutus
DPP4
-
 Crocodylus acutus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
5 40 the activity exhibits a nearly linear increase with temperature over 5-40°C Crocodylus acutus