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Literature summary for 3.4.14.5 extracted from
- Expression pattern of dipeptidyl peptidase IV activity and/or structure homologues in cancer (2009), Folia Biol. (Praha), 55, 77-84.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Homo sapiens | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
2 * 110000, calculated from amino acid sequence | Homo sapiens |
| 240000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | DPP-IV typically cleaves Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of peptides | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
| cardiac muscle | - |
Homo sapiens | - |
| cerebrospinal fluid | - |
Homo sapiens | - |
| colon adenocarcinoma cell | - |
Homo sapiens | - |
| endometrial cancer cell | - |
Homo sapiens | - |
| endothelial cell | - |
Homo sapiens | - |
| epithelial cell | DPP-IV is localized only in epithelial cells of vessels of the blood-brain barrier and on ependyma | Homo sapiens | - |
| fibroblast | - |
Homo sapiens | - |
| follicular thyroid cancer cell | - |
Homo sapiens | - |
| glioma cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| lymphocyte | - |
Homo sapiens | - |
| melanoma cell | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | DPP-IV typically cleaves Xaa-Pro or Xaa-Ala dipeptides from the N-terminus of peptides | Homo sapiens | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 110000, calculated from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dipeptidyl peptidase IV | - |
Homo sapiens |
| DPP-IV | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | DPP-IV mRNA and protein levels are null or markedly reduced in non-small cell lung cancer cell lines, endometrial cancer, colon adenocarcinoma, and melanoma cells | down |
| Homo sapiens | DPP-IV protein expression is up-regulated in thyroid cancer, lung cancer, follicular thyroid cancer, and glioma | up |
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Release 2023.1 (January 2023)
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