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Literature summary for 3.4.14.5 extracted from

  • Yu, D.M.; Yao, T.W.; Chowdhury, S.; Nadvi, N.A.; Osborne, B.; Church, W.B.; McCaughan, G.W.; Gorrell, M.D.
    The dipeptidyl peptidase IV family in cancer and cell biology (2010), FEBS J., 277, 1126-1144.
    View publication on PubMed

Application

Application Comment Organism
medicine DPIV is a type 2 diabetes therapeutic target Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sitagliptin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Homo sapiens
-
?
-
?
neuropeptide Y + H2O Homo sapiens
-
?
-
?
stromal cell-derived factor-1 + H2O Homo sapiens
-
?
-
?
Substance P + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27487
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell chronic lymphocytic leukemia cell
-
Homo sapiens
-
capillary endothelial cell
-
Homo sapiens
-
endometrial adenocarcinoma cell
-
Homo sapiens
-
epithelial cell
-
Homo sapiens
-
esophageal cancer cell
-
Homo sapiens
-
gut
-
Homo sapiens
-
hepatocellular carcinoma cell
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung adenocarcinoma cell
-
Homo sapiens
-
lymph node
-
Homo sapiens
-
mucous gland acinar cells of mucous glands Homo sapiens
-
ovarian carcinoma cell
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-
salivary gland acinar cells of salivary glands Homo sapiens
-
spleen
-
Homo sapiens
-
thymus
-
Homo sapiens
-
thyroid carcinoma cell
-
Homo sapiens
-
uterus
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
Homo sapiens ?
-
?
neuropeptide Y + H2O
-
Homo sapiens ?
-
?
stromal cell-derived factor-1 + H2O
-
Homo sapiens ?
-
?
Substance P + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CD26
-
Homo sapiens
dipeptidyl peptidase IV
-
Homo sapiens
DPIV
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens DPIV expression is progressively downregulated in endometrial adenocarcinoma down