Any feedback?
Literature summary for 3.4.14.5 extracted from
- Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo (2008), J. Immunol., 181, 1120-1127.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | CCL11 application leads to an up-regulation of DPPIV, which is not associated with negative feedback inhibition via DPPIV-cleaved CCL11(3-74) | Homo sapiens | |
| additional information | CCL11 application leads to an up-regulation of DPPIV, which is not associated with negative feedback inhibition via DPPIV-cleaved CCL11(3-74) | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| isoleucine thiazolidide | - |
Homo sapiens |  |
| isoleucine thiazolidide | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CCL11 + H2O | Homo sapiens | - |
CCL11(3-74) + ? | - |
? | |
| CCL11 + H2O | Rattus norvegicus | - |
CCL11(3-74) + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eosinophil | - |
Homo sapiens | - |
| eosinophil | - |
Rattus norvegicus | - |
| epidermis | - |
Rattus norvegicus | - |
| fascia | - |
Rattus norvegicus | - |
| hair follicle | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CCL11 + H2O | - |
Homo sapiens | CCL11(3-74) + ? | - |
? | |
| CCL11 + H2O | - |
Rattus norvegicus | CCL11(3-74) + ? | - |
? | |
| Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
| Gly-L-Pro-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | Gly-L-Pro + 7-amino-4-methylcoumarin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CD26 | - |
Homo sapiens |
| CD26 | - |
Rattus norvegicus |
| dipeptidyl peptidase IV | - |
Homo sapiens |
| dipeptidyl peptidase IV | - |
Rattus norvegicus |
| DPPIV | - |
Homo sapiens |
| DPPIV | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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