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Literature summary for 3.4.14.5 extracted from

  • Moritoh, Y.; Takeuchi, K.; Asakawa, T.; Kataoka, O.; Odaka, H.
    The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice (2009), Eur. J. Pharmacol., 602, 448-454.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
alogliptin i.e. 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]benzonitrilemonobenzoate, about 80% inhibition of DPP-4 after 4-week treatment with 45.7 mg/kg/day (0.03%) alogliptin Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glucagon-like peptide 1 + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glucagon-like peptide 1 + H2O
-
 Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase-4
-
 Mus musculus
DPP-4
-
 Mus musculus