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Literature summary for 3.4.14.5 extracted from

  • Liang, G.B.; Qian, X.; Biftu, T.; Singh, S.; Gao, Y.D.; Scapin, G.; Patel, S.; Leiting, B.; Patel, R.; Wu, J.; Zhang, X.; Thornberry, N.A.; Weber, A.E.
    Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design (2008), Bioorg. Med. Chem. Lett., 18, 3706-3710.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
(1R)-1-(4-bromophenyl)-2-(2,5-difluorophenyl)ethanamine
-
 Homo sapiens
(1R)-1-[4-(3-chloropyridin-4-yl)phenyl]-2-(2,5-difluorophenyl)ethanamine
-
 Homo sapiens
(1R)-2-(2,5-difluorophenyl)-1-(4-pyridin-4-ylphenyl)ethanamine
-
 Homo sapiens
(2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
 Homo sapiens
(2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
-
 Homo sapiens
(2R,3R)-1-(2,5-difluorophenyl)-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
-
 Homo sapiens
(2R,3R)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Homo sapiens
(2R,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
-
 Homo sapiens
(2S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
-
 Homo sapiens
(2S,3S)-1-oxo-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
-
 Homo sapiens
(2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(4-pyridin-4-ylphenyl)butan-2-amine
-
 Homo sapiens
(2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
 Homo sapiens
(2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
 Homo sapiens
(2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
 Homo sapiens
(2S,3S)-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
-
 Homo sapiens
(3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one
-
 Homo sapiens
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
 Homo sapiens
(3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
 Homo sapiens
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
-
 Homo sapiens
(3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-methyl-1,4-diazepan-2-one
-
 Homo sapiens
(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-1-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxobutan-1-one
-
 Homo sapiens
1-[(2S)-2-amino-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butyl]piperidin-2-one
-
 Homo sapiens
4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide
-
 Homo sapiens
4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxamide
-
 Homo sapiens
[(2S)-1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidin-2-yl]methanol
-
 Homo sapiens
[(2S)-1-[(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoyl]pyrrolidin-2-yl]methanol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Homo sapiens
DPP-4
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
-
 Homo sapiens (3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-methyl-1,4-diazepan-2-one
0.000032
-
-
 Homo sapiens 4'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide
0.00004
-
-
 Homo sapiens (2S,3S)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
0.00004
-
-
 Homo sapiens (3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
0.000046
-
-
 Homo sapiens (2R,3R)-3-[3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000055
-
-
 Homo sapiens (3R)-3-amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one
0.000071
-
-
 Homo sapiens (2S,3S)-3-[4-(3-chloropyridin-4-yl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
0.000085
-
-
 Homo sapiens (3R)-4-[(3R)-3-amino-4-(2-fluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
0.000098
-
-
 Homo sapiens (2R)-1-(2-fluorophenyl)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butan-2-amine
0.0001
-
-
 Homo sapiens 4'-[(1S,2S)-2-amino-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl]biphenyl-3-carboxamide
0.000107
-
-
 Homo sapiens (1R)-1-[4-(3-chloropyridin-4-yl)phenyl]-2-(2,5-difluorophenyl)ethanamine
0.00011
-
-
 Homo sapiens (2S,3S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxo-3-(4-pyridin-4-ylphenyl)butan-2-amine
0.00012
-
-
 Homo sapiens (3R)-4-[(3S)-3-amino-4-(2-oxopiperidin-1-yl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
0.00012
-
-
 Homo sapiens 1-[(2S)-2-amino-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]butyl]piperidin-2-one
0.0002
-
-
 Homo sapiens [(2S)-1-[(3R)-3-amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidin-2-yl]methanol
0.000245
-
-
 Homo sapiens (2S,3S)-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
0.000253
-
-
 Homo sapiens (1R)-2-(2,5-difluorophenyl)-1-(4-pyridin-4-ylphenyl)ethanamine
0.00027
-
-
 Homo sapiens (2R)-1-(2,5-difluorophenyl)-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-amine
0.0006
-
-
 Homo sapiens (2R,3R)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
0.000615
-
-
 Homo sapiens (2S,3S)-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine
0.0013
-
-
 Homo sapiens (1R)-1-(4-bromophenyl)-2-(2,5-difluorophenyl)ethanamine
0.0018
-
-
 Homo sapiens (2S,3S)-1-oxo-1-pyrrolidin-1-yl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
0.0044
-
-
 Homo sapiens (2R,3R)-1-(2,5-difluorophenyl)-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]butan-2-amine
0.0088
-
-
 Homo sapiens (3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-1-(3-methyl-1,2,4-oxadiazol-5-yl)-4-oxobutan-1-one
0.0092
-
-
 Homo sapiens [(2S)-1-[(3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoyl]pyrrolidin-2-yl]methanol
0.0098
-
-
 Homo sapiens (2S)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxo-4-(1,3-thiazolidin-3-yl)butan-2-amine