Literature summary for 3.4.14.5 extracted from

Chu, X.Y.; Bleasby, K.; Yabut, J.; Cai, X.; Chan, G.H.; Hafey, M.J.; Xu, S.; Bergman, A.J.; Braun, M.P.; Dean, D.C.; Evers, R.
Transport of the dipeptidyl peptidase-4 inhibitor sitagliptin by human organic anion transporter 3, organic anion transporting polypeptide 4C1, and multidrug resistance P-glycoprotein (2007), J. Pharmacol. Exp. Ther., 321, 673-683.

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Inhibitors

Inhibitors	Comment	Organism	Structure
sitagliptin	inhibitor for the treatment of type 2 diabetes, is excreted into the urine via active tubular secretion and glomerular filtration in humans. Sitagliptin is transported by human organic anion transporter hOAT3, organic anion transporting polypeptide OATP4C1, and multidrug resistance (MDR) P-glycoprotein, but not by human organic cation transporter 2 hOCT2, hOAT1, oligopeptide transporter hPEPT1, OATP2B1, and the multidrug resistance proteins MRP2 and MRP4	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
dipeptidyl peptidase-4	-	Homo sapiens

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Release 2023.1 (January 2023)