Application | Comment | Organism |
---|---|---|
medicine | DPP-IV inhibitors are potentially important therapies in diabetes | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-1-[N-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl]pyrrolidine-2-carbonitrile | - |
Homo sapiens | |
saxagliptin | - |
Homo sapiens | |
sitagliptin | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide-1 + H2O | Homo sapiens | DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucagon-like peptide-1 into metabolites that are devoid of insulin-releasing activity | ? | - |
? | |
glucose-dependent insulinotropic polypeptide + H2O | Homo sapiens | DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucose-dependent insulinotropic polypeptide into metabolites that are devoid of insulin-releasing activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glucagon-like peptide-1 + H2O | - |
Homo sapiens | ? | - |
? | |
glucagon-like peptide-1 + H2O | DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucagon-like peptide-1 into metabolites that are devoid of insulin-releasing activity | Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic polypeptide + H2O | - |
Homo sapiens | ? | - |
? | |
glucose-dependent insulinotropic polypeptide + H2O | DPP-IV is the main proteolytic enzyme responsible for the rapid inactivation of glucose-dependent insulinotropic polypeptide into metabolites that are devoid of insulin-releasing activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DPP-IV | - |
Homo sapiens |