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Literature summary for 3.4.14.5 extracted from

  • Tran, T.; Quan, C.; Edosada, C.Y.; Mayeda, M.; Wiesmann, C.; Sutherlin, D.; Wolf, B.B.
    Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP (2007), Bioorg. Med. Chem. Lett., 17, 1438-1442.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
N-[2-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-2-oxoethyl]-N-methyl-5-oxoprolinamide
-
 Homo sapiens
[(2R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-(N-acetyl-N-methylglycyl)pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-(N-acetylglycyl)pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[(2-oxopyridin-1(2H)-yl)acetyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-(2,2-dimethylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-(cyclohexylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-(cyclopentylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-methyl-N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-methyl-N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens
[(2R)-1-[N-[(2,5-dichlorophenyl)carbonyl]glycyl]pyrrolidin-2-yl]boronic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
DPP4
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000068
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid
0.000377
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-(N-acetylglycyl)pyrrolidin-2-yl]boronic acid
0.00143
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-(methylsulfonyl)glycyl]pyrrolidin-2-yl]boronic acid
0.0043
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
0.0046
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-methyl-N-(2-methylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid
0.006871
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-(N-acetyl-N-methylglycyl)pyrrolidin-2-yl]boronic acid
0.007391
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-(cyclohexylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
0.00908
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-(cyclopentylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
0.0095
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-[(2,5-dichlorophenyl)carbonyl]glycyl]pyrrolidin-2-yl]boronic acid
0.0113
-
 23°C, pH 7.4 Homo sapiens N-[2-[(2R)-2-(dihydroxyboranyl)pyrrolidin-1-yl]-2-oxoethyl]-N-methyl-5-oxoprolinamide
0.0195
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-methyl-N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
0.0227
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetyl]pyrrolidin-2-yl]boronic acid
0.0384
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-(phenylcarbonyl)glycyl]pyrrolidin-2-yl]boronic acid
0.182
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[(2-oxopyridin-1(2H)-yl)acetyl]pyrrolidin-2-yl]boronic acid
0.451
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-(4-oxo-4-phenylbutanoyl)pyrrolidin-2-yl]boronic acid
0.608
-
 23°C, pH 7.4 Homo sapiens [(2R)-1-[N-(2,2-dimethylpropanoyl)glycyl]pyrrolidin-2-yl]boronic acid