Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3-benzyl-4-oxido-3H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-aminium | - |
Homo sapiens | |
1-[1-(2-chlorobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium | - |
Rattus norvegicus | |
1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | potent and selective DPPIV inhibitor, but it showed a significant loss of activity in the presence of plasma | Homo sapiens | |
1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | - |
Rattus norvegicus | |
1-[1-(2-cyanobenzyl)-5-methyl-4-oxo-4,5-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[1-(2-cyanobenzyl)-6-methyl-7-oxo-3a,6,7,7a-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[1-(3-cyanobenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[1-[3-(cyanomethyl)benzyl]-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[4,9-dioxo-1-[2-(trifluoromethyl)benzyl]-4,9-dihydro-1H-naphtho[2,3-d]imidazol-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[5-benzyl-1-(3-cyanobenzyl)-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethoxy)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethyl)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium | - |
Homo sapiens | |
1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium | - |
Rattus norvegicus | |
1-[7-fluoro-6-methoxy-1-[2-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]piperidin-3-aminium | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | P14740 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase IV | - |
Homo sapiens |
dipeptidyl peptidase IV | - |
Rattus norvegicus |
h-DPPIV | - |
Homo sapiens |
h-DPPIV | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
- |
Homo sapiens | 1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium | |
0.000002 | - |
in absence of plasma | Rattus norvegicus | 1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | |
0.000002 | - |
potent and selective DPPIV inhibitor, but it showed a significant loss of activity in the presence of plasma | Homo sapiens | 1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | |
0.000003 | - |
in absence of plasma | Rattus norvegicus | 1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium | |
0.000005 | - |
- |
Homo sapiens | 1-[1-(2-cyanobenzyl)-6-methyl-7-oxo-3a,6,7,7a-tetrahydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium | |
0.000007 | - |
in presence of 18% plasma | Rattus norvegicus | 1-[7-(2-cyanobenzyl)-1,3-dimethyl-2,6-dioxo-2,3,4,5,6,7-hexahydro-1H-purin-8-yl]piperidin-3-aminium | |
0.000009 | - |
- |
Homo sapiens | 1-[1-(2-chlorobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | |
0.00001 | - |
- |
Homo sapiens | 1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethyl)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | |
0.000011 | - |
- |
Homo sapiens | 1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium | |
0.000011 | - |
- |
Homo sapiens | 1-[1-[3-(cyanomethyl)benzyl]-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium | |
0.000017 | - |
in absence of plasma | Rattus norvegicus | 1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium | |
0.000022 | - |
- |
Homo sapiens | 1-[5-methyl-4,6-dioxo-1-[2-(trifluoromethoxy)benzyl]-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | |
0.000024 | - |
in presence of 18% plasma | Rattus norvegicus | 1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium | |
0.000025 | - |
- |
Homo sapiens | 1-[4,9-dioxo-1-[2-(trifluoromethyl)benzyl]-4,9-dihydro-1H-naphtho[2,3-d]imidazol-2-yl]piperidin-3-aminium | |
0.000029 | - |
- |
Homo sapiens | 1-[5-benzyl-1-(3-cyanobenzyl)-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | |
0.000057 | - |
- |
Homo sapiens | 1-[7-fluoro-6-methoxy-1-[2-(trifluoromethyl)benzyl]-1H-benzimidazol-2-yl]piperidin-3-aminium | |
0.00026 | - |
- |
Homo sapiens | 1-[1-(2-cyanobenzyl)-5-methyl-4-oxo-4,5-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium | |
0.0003 | - |
- |
Homo sapiens | 1-(3-benzyl-4-oxido-3H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-aminium | |
0.00045 | - |
- |
Homo sapiens | 1-[1-(2-cyanobenzyl)-4,5-bis(methylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-aminium | |
0.0006 | - |
in presence of 18% plasma | Rattus norvegicus | 1-[1-(2-cyanobenzyl)-5-methyl-4,6-dioxo-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl]piperidin-3-aminium | |
0.0012 | - |
- |
Homo sapiens | 1-[1-(3-cyanobenzyl)-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperidin-3-aminium |