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Literature summary for 3.4.14.5 extracted from

  • Lorey, S.; Stockel-Maschek, A.; Faust, J.; Brandt, W.; Stiebitz, B.; Gorrell, M.D.; Kahne, T.; Mrestani-Klaus, C.; Wrenger, S.; Reinhold, D.; Ansorge, S.; Neubert, K.
    Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites (2003), Eur. J. Biochem., 270, 2147-2156.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
human HIV-1 Gly3-Tat(1-9) peptide amino acid sequence MDGVDPNIE, parabolic mixed type inhibition Homo sapiens
human HIV-1 Ile3-Tat(1-9) peptide amino acid sequence MDIVDPNIE, parabolic mixed type inhibition Homo sapiens
human HIV-1 Lys2-Tat(1-9) peptide amino acid sequence MKPVDPNIE, linear mixed type inhibition Homo sapiens
human HIV-1 Tat protein viral protein, inhibits the enzyme activity and cell proliferation Homo sapiens
human HIV-1 Tat(1-9) peptide amino acid sequence MDPVDPNIE, N-terminal peptide of the viral Tat protein, inhibits the enzyme activity and cell proliferation, parabolic mixed type inhibition Homo sapiens
human HIV-1 Trp1-Tat(1-9) peptide amino acid sequence WDPVDPNIE, parabolic mixed type inhibition Homo sapiens
human HIV-1 Trp2-Tat(1-9) peptide amino acid sequence MWPVDPNIE, linear mixed type inhibition Homo sapiens
interleukin-2 peptide Met-IL-2(1-12) amino acid sequence MAPTSSSTKKTQL, linear mixed type inhibition Homo sapiens
interleukin-2 peptide Met-TRp1-IL-2(1-8) amino acid sequence MWPTSSSTK, competitive inhibition Homo sapiens
Met-Trp-Pro competitive inhibition Homo sapiens
Met-Trp-Val linear-mixed type inhibition Homo sapiens
Met-Trp1-G-CSF(1-8) peptide amino acid sequence MWPLGPASS, G-CSF is the granulocyte colony stimulating factor, linear mixed type inhibition Homo sapiens
Pro-Pro-[OPh-4 Cl]2 irreversible Homo sapiens
thromboxane A2 receptor peptide TXA2-R(1-9) N-terminal MWP sequence motif MWPNGSSLG, potent competitive inhibitor, possibly functionally involved in antigen presentation by inhibiting T-cell expressed enzyme Homo sapiens
Trp2,Ile3-Tat(1-9) peptide amino acid sequence MWIVDPNIE, competitive inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme plays an important role in the activation and proliferation of lymphocytes ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline reaction mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Homo sapiens
-
T-cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Pro-4-nitroanilide + H2O
-
 Homo sapiens Ala-Pro + 4-nitroaniline
-
 ?
additional information enzyme plays an important role in the activation and proliferation of lymphocytes Homo sapiens ?
-
 ?
N-(Gly-Pro)-N'-(5-chloropentanoyl)-rhodamine 110 + H2O
-
 Homo sapiens Gly-Pro + N-(5-chloropentanoyl)-rhodamine 110
-
 ?

Synonyms

Synonyms Comment Organism
CD26
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Homo sapiens
DP IV
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Homo sapiens
0.002
-
 human HIV-1 Trp2-Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.005
-
 thromboxane A2 receptor peptide TXA2-R(1-9) pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.012
-
 Met-Trp1-G-CSF(1-8) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.016
-
 interleukin-2 peptide Met-TRp1-IL-2(1-8) pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.025
-
 Met-Trp-Pro pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.043
-
 human HIV-1 Lys2-Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.044
-
 Trp2,Ile3-Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.15
-
 human HIV-1 Trp1-Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.2
-
 Met-Trp-Val pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.23
-
 human HIV-1 Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme, versus substrate Gly-Pro-rhodamine R110-CO-(CH2)4Cl Homo sapiens
0.267
-
 human HIV-1 Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.269
-
 interleukin-2 peptide Met-IL-2(1-12) pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
0.487
-
 human HIV-1 Gly3-Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens
1.75
-
 human HIV-1 Ile3-Tat(1-9) peptide pH 7.6, 30°C, recombinant, soluble enzyme Homo sapiens