Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.14.5 extracted from

  • Stoeckel-Maschek, A.; Stiebitz, B.; Faust, J.; Born, I.; Kaehne, T.; Gorrell, M.D.; Neubert, K.
    Different inhibition mechanisms of dipeptidyl peptidase IV by tryptophan containing peptides and amides (2003), Adv. Exp. Med. Biol., 524, 69-72.
    View publication on PubMed
Search for more literature for 3.4.14.5

Inhibitors

Inhibitors Comment Organism Structure
Ile-Pro competitive Homo sapiens
Ile-Pro competitive Sus scrofa
Ile-pyrrolidide competitive Homo sapiens
Ile-pyrrolidide competitive Sus scrofa
Ile-thiazolidide competitive Homo sapiens
Ile-thiazolidide competitive Sus scrofa
Nepsilon-nitrobenzyloxycarbonyl-Lys-Pro competitive Homo sapiens
Nepsilon-nitrobenzyloxycarbonyl-Lys-Pro competitive Sus scrofa
Nepsilon-nitrobenzyloxycarbonyl-Lys-pyrrolidide competitive Homo sapiens
Nepsilon-nitrobenzyloxycarbonyl-Lys-pyrrolidide competitive Sus scrofa
Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolidide competitive Homo sapiens
Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolidide competitive Sus scrofa
Phe-Pro-PSI[P(OEt)2] diastereomeric mixture, competitive Homo sapiens
Phe-Pro-PSI[P(OEt)2] diastereomeric mixture, competitive Sus scrofa
Trp-Pro linear mixed-type Homo sapiens
Trp-Pro linear mixed-type Sus scrofa
Trp-pyrrolidide competitive Homo sapiens
Trp-pyrrolidide competitive Sus scrofa
Trp-thiazolidide competitive Homo sapiens
Trp-thiazolidide competitive Sus scrofa

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline proline specific serine protease Homo sapiens
a
release of an N-terminal dipeptide, Xaa-Yaa-/-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline proline specific serine protease Sus scrofa
a

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Pro-4-nitroanilide + H2O
-
 Sus scrofa Ala-Pro + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
dipeptidyl peptidase IV
-
 Homo sapiens
dipeptidyl peptidase IV
-
 Sus scrofa
DPP IV
-
 Homo sapiens
DPP IV
-
 Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
 assay at Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000092
-
 Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolidide pH 7.6, 30°C Sus scrofa
0.00013
-
 Ile-thiazolidide pH 7.6, 30°C Sus scrofa
0.00014
-
 Nepsilon-nitrobenzyloxycarbonyl-Lys-thiazolidide
-
 Homo sapiens
0.00022
-
 Ile-thiazolidide
-
 Homo sapiens
0.00022
-
 Ile-pyrrolidide pH 7.6, 30°C Sus scrofa
0.00027
-
 Nepsilon-nitrobenzyloxycarbonyl-Lys-pyrrolidide pH 7.6, 30°C Sus scrofa
0.00042
-
 Nepsilon-nitrobenzyloxycarbonyl-Lys-pyrrolidide
-
 Homo sapiens
0.00055
-
 Ile-pyrrolidide
-
 Homo sapiens
0.002
-
 Trp-pyrrolidide pH 7.6, 30°C Sus scrofa
0.0079
-
 Trp-thiazolidide
-
 Homo sapiens
0.008
-
 Trp-thiazolidide pH 7.6, 30°C Sus scrofa
0.012
-
 Nepsilon-nitrobenzyloxycarbonyl-Lys-Pro pH 7.6, 30°C Sus scrofa
0.015
-
 Ile-Pro pH 7.6, 30°C Sus scrofa
0.0186
-
 Trp-pyrrolidide
-
 Homo sapiens
0.0247
-
 Nepsilon-nitrobenzyloxycarbonyl-Lys-Pro
-
 Homo sapiens
0.0292
-
 Ile-Pro
-
 Homo sapiens
0.044
-
 Trp-Pro-PSI[P(OEt)2] diastereomer 1 pH 7.6, 30°C Sus scrofa
0.057
-
 Trp-Pro pH 7.6, 30°C Sus scrofa
0.076
-
 Phe-Pro-PSI[P(OEt)2] diastereomeric mixture pH 7.6, 30°C Sus scrofa
0.136
-
 Phe-Pro-PSI[P(OEt)2]
-
 Homo sapiens
0.185
-
 Trp-Pro
-
 Homo sapiens
1.23
-
 Pro-Pro-PSI[P(OEt)2] diastereomeric mixture pH 7.6, 30°C Sus scrofa