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Literature summary for 3.4.14.4 extracted from
- Alteration of rat dipeptidyl peptidase III by site-directed mutagenesis: Cysteine176 is a regulatory residue for the enzyme activity (2000), Biochem. Biophys. Res. Commun., 276, 553-558.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C147A | activity similar to wild type | Rattus norvegicus |
| C176A | 25-35% of wild type activity, resistant against p-chloro-mercuri-benzoate and N-ethylmaleimide | Rattus norvegicus |
| C176E | no enzymic activity | Rattus norvegicus |
| C176G | no enzymic activity | Rattus norvegicus |
| C19A | activity similar to wild type | Rattus norvegicus |
| C509A | activity similar to wild type | Rattus norvegicus |
| C519A | activity similar to wild type | Rattus norvegicus |
| C654A | activity similar to wild type | Rattus norvegicus |
| C701A | activity similar to wild type | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-ethylmaleimide | complete inhibition at 2 mM | Rattus norvegicus |  |
| p-chloromercuribenzoate | complete inhibition at 0.001 mM | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | one mole per mole of protein | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
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Release 2023.1 (January 2023)
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