Literature summary for 3.4.14.2 extracted from

Leiting, B.; Pryor, K.D.; Wu, J.K.; Marsilio, F.; Patel, R.A.; Craik, C.S.; Ellman, J.A.; Cummings, R.T.; Thornberry, N.A.
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII (2003), Biochem. J., 371, 525-532.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Diprotin A	not selective for the enzyme	Homo sapiens
Ile cyanothiazolidide	not selective for the enzyme	Homo sapiens
Lys piperidide	not selective for the enzyme	Homo sapiens
Lys thiazolidide	not selective for the enzyme	Homo sapiens
threo-Ile thiazolidide	not selective for the enzyme	Homo sapiens
Val pyrrolidide	not selective for the enzyme	Homo sapiens
Val thiazolidide	not selective for the enzyme	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.003	-	Nle-Pro-7-amido-4-methylcoumarin	pH 7.5, 37°C	Homo sapiens
0.003	-	Nle-Pro-rhodamine	pH 7.5, 37°C	Homo sapiens
0.006	-	Nle-Nle-rhodamine	pH 7.5, 37°C	Homo sapiens
0.011	-	Lys-Pro-7-amido-4-methylcoumarin	pH 7.5, 37°C	Homo sapiens
0.032	-	Ala-Pro-amino-4-trifluoromethylcoumarin	pH 7.5, 37°C	Homo sapiens
0.149	-	Gly-Pro-7-amido-4-methylcoumarin	pH 7.5, 37°C	Homo sapiens
0.215	-	Lys-Ala-7-amido-4-methylcoumarin	pH 7.5, 37°C	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosomal	-	Homo sapiens	-	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UHL4	-	-

Purification (Commentary)

Purification (Comment)	Organism
from placenta	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O	-	Homo sapiens	Ala-Pro + amino-4-trifluoromethylcoumarin	-	?
Gly-Ala-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Gly-Ala + 7-amino-4-methylcoumarin	-	?
Gly-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Gly-Pro + 7-amino-4-methylcoumarin	-	?
Lys-Ala-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Lys-Ala + 7-amino-4-methylcoumarin	-	?
Lys-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Lys-Pro + 7-amino-4-methylcoumarin	-	?
additional information	specific for Pro at position P1	Homo sapiens	?	-	?
Nle-Nle-rhodamine + H2O	-	Homo sapiens	Nle-Nle + rhodamine	-	?
Nle-Pro-7-amido-4-methylcoumarin + H2O	-	Homo sapiens	Nle-Pro + 7-amino-4-methylcoumarin	-	?
Nle-Pro-rhodamine + H2O	-	Homo sapiens	Nle-Pro + rhodamine	-	?

Synonyms

Synonyms	Comment	Organism
dipeptidyl peptidase	-	Homo sapiens
DPP-II	-	Homo sapiens
More	enzyme belongs to the Pro-X carboxypeptidase family S28	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
5.5	6	-	Homo sapiens

pH Range

pH Minimum	pH Maximum	Comment	Organism
3.5	8.5	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00017	-	Lys thiazolidide	pH 7.5, 37°C	Homo sapiens
0.00056	-	Ile cyanothiazolidide	pH 7.5, 37°C	Homo sapiens
0.00065	-	Lys piperidide	pH 7.5, 37°C	Homo sapiens
0.0097	-	threo-Ile thiazolidide	pH 7.5, 37°C	Homo sapiens
0.0153	-	Val thiazolidide	pH 7.5, 37°C	Homo sapiens
0.0408	-	Diprotin A	pH 7.5, 37°C	Homo sapiens
0.1	-	Val pyrrolidide	above, pH 7.5, 37°C	Homo sapiens

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Release 2023.1 (January 2023)