Application | Comment | Organism |
---|---|---|
medicine | TPP2 mRNA and protein are significantly up-regulated in oral squamous cell carcinoma-derived cells compared with human normal oral keratinocytes. Suppression of TPP2 expression with shRNA significantly inhibit cellular proliferation compared with the control cells. In addition, appropriate localization of cellular proliferation and spindle assembly checkpoint molecules MAD2 and upregulation of CCNB1 are observed in TPP2 knockdown oral squamous cell carcinoma cells. TPP2 expression in primary oral squamous cell carcinomas is significantly greater than that in the normal oral counterparts, and the TPP2-positive cases are significantly correlated with tumor size | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P29144 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Ca9-22 cell | - |
Homo sapiens | - |
HO-1-N-1 cell | - |
Homo sapiens | - |
HSC-2 cell | - |
Homo sapiens | - |
HSC-3 cell | - |
Homo sapiens | - |
HSC-4 cell | - |
Homo sapiens | - |
oral squamous cell carcinoma cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
TPP II | - |
Homo sapiens |
tripeptidyl aminopeptidase I I | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | highly up-regulated in oral squamous cell carcinoma-derived cells | up |
Homo sapiens | TPP2 mRNA and protein are significantly up-regulated in oral squamous cell carcinoma-derived cells compared with human normal oral keratinocytes | up |
General Information | Comment | Organism |
---|---|---|
malfunction | suppression of TPP2 expression with shRNA significantly inhibits cellular proliferation compared with the control cells | Homo sapiens |