Cloned (Comment) | Organism |
---|---|
overexpression in 293-cells, enzyme forms active oligomers | Mus musculus |
overexpression in 293-cells, enzyme i mainly in a nonassociated, inactive state | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the recombinant human TPP II and murine TPP II display different association/dissociation characteristics when overexpressed in human 293-cells. The human enzyme is mainly in a nonassociated, inactive state, whereas the murine enzyme forms active oligomers. The formation of the active complex is profoundly influenced by a single amino acid difference: Gly252 in mouse and Arg252 in human | Mus musculus |
additional information | the recombinant human TPP II and murine TPP II display different association/dissociation characteristics when overexpressed in human 293-cells. The human enzyme is mainly in a nonassociated, inactive state, whereas the murine enzyme forms active oligomers. The formation of the active complex is profoundly influenced by a single amino acid difference: Gly252 in mouse and Arg252 in human | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
More | compared with other subtilases, TPP II has a 200 amino-acid insertion between the catalytic Asp44 and His264 residues and is active as an oligomeric complex. The insert is important for the formation of the active high-molecular mass complex | Mus musculus |
More | compared with other subtilases, TPP II has a 200 amino-acid insertion between the catalytic Asp44 and His264 residues and is active as an oligomeric complex. The insert is important for the formation of the active high-molecular mass complex | Homo sapiens |