Literature summary for 3.4.14.10 extracted from

Tomkinson, B.; Grehn, L.; Fransson, B.; Zetterquist, ?.
Use of a dehydroalanine-containing peptide as an efficient inhibitor of tripeptidyl peptidase II (1994), Arch. Biochem. Biophys., 314, 276-279.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Arg-Ala-(dehydro)Ala-Val-Ala	-	Homo sapiens
Arg-Ala-(phospho)Ser-Val-Ala	-	Homo sapiens
Arg-Arg-Ala-(dehydro)Ala-Val-Ala	less effective than Arg-Ala-(dehydro)Ala-Val-Ala	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
erythrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Arg-Ala-(dehydro)Ala-Val-Ala + H2O	inhibitor, at 0.05% the rate of Arg-Arg-Ala-(phospho)Ser-Val-Ala hydrolysis	Homo sapiens	?	-	?
Arg-Arg-Ala-(phospho)Ser-Val-Ala + H2O	-	Homo sapiens	Arg-Arg-Ala + (phospho)Ser-Val-Ala	-	?
additional information	-	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)