Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Synonyms | Comment | Organism |
---|---|---|
dipeptidyl peptidase I | - |
Mus musculus |
DPPI | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | survival in DPPI-/- mice lacking dipeptidyl peptidase I is significantly better than in DPPI+/+ mice 8 d after infection in a Klebsiella pneumoniae lung infection model. DPPI-/- mice have significantly fewer bacteria in the lung than infected DPPI+/+ mice, but no difference in lung histopathology, lung injury, or cytokine levels. Levels of surfactant protein D, but not of surfactant protein A, are higher in DPPI-/- than in DPPI+/+ BAL fluid, and DPPI-/- BAL fluid aggregate bacteria more effectively than control BAL fluid. Sequencing of the amino terminus of surfactant protein D reveals two or eight additional amino acids in surfactant protein D isolated from DPPI-/- mice, suggesting processing by DPPI | Mus musculus |