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Literature summary for 3.4.14.1 extracted from

  • Metrione, R.M.; MacGeorge, N.L.
    The mechanism of action of dipeptidyl aminopeptidase. Inhibition by amino acid derivatives and amines; activation by aromatic compounds (1975), Biochemistry, 14, 5249-5252.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phenol activates reaction with Gly-Gly-ethyl ester and Gly-Gly-NH2, no effect on reaction with Gly-Phe-NH2 Bos taurus
Pyridine activates reaction with Gly-Gly-ethyl ester and Gly-Gly-NH2, no effect on reaction with Gly-Phe-NH2 Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
5-aminopentanoic acid ethyl ester
-
Bos taurus
Arg-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
benzoyl-Arg-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
beta-Ala-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
beta-alanine ethyl ester
-
Bos taurus
Butylamine reaction with Gly-Gly-ethyl ester, Gly-Gly-NH2 or Gly-Phe-NH2 Bos taurus
ethylamine
-
Bos taurus
gamma-aminobutyryl ethyl ester
-
Bos taurus
Glu-alpha-methyl ester inhibition of the reaction with Gly-Gly-ethyl ester, weak inhibition of reaction with Gly-L-Phe-NH2 Bos taurus
Gly-beta-Ala-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
Gly-Gly-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
Gly-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
glycinamide reaction with Gly-Gly-ethyl ester, Gly-Gly-NH2 or Gly-Phe-NH2 Bos taurus
glycine ethyl ester
-
Bos taurus
Hexylamine
-
Bos taurus
Leu-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
Lys-NH2 inhibition of the reaction with Gly-Gly-ethyl ester, weak inhibition of reaction with Gly-L-Phe-NH2 Bos taurus
methylamine
-
Bos taurus
pentylamine
-
Bos taurus
Phe-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus
Propylamine
-
Bos taurus
Trp-NH2 inhibition of the reaction with Gly-Gly-ethyl ester or Gly-L-Phe-NH2 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Bos taurus
-