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Literature summary for 3.4.13.9 extracted from
- Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells (2010), Mol. Cell. Biochem., 340, 15-20.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| betulinic acid | i.e. 3beta-hdroxy-lup-20(29)-en-28-oic acid, inhibits the enzyme and is involved in anti-angiogenesis due to further inhibition of expression and decrease in expressions of alpha1 and alpha2 integrins, hypoxia-inducible factor 1, HIF-1, and vascular endothelial cell growth factor, detailed overview | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| uterine adenocarcinoma cell | Ishikawa cell line | Homo sapiens | - |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | prolidase may play a role in angiogenesis | Homo sapiens |
| metabolism | prolidase catalyzes the final step of collagen degradation | Homo sapiens |
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Release 2023.1 (January 2023)
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