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Literature summary for 3.4.13.9 extracted from
- Activity of prolidase isoenzymes in the rat brain: subcellular and regional distribution during development (2009), Brain Res., 1303, 8-14.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-Benzyloxycarbonyl-L-proline | inhibits PD I, but not PD II | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | PD I is completely cytosolic, while PD II also occurs in the particulate fraction | Rattus norvegicus | 5829 | - |
| additional information | PD II is cytosolic and also occurs in the particulate fraction | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | activates | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
isoenzymes PD I and PD II | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| separation of native isozymes PD I and PD II from brain homogenate by gel filtration | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | isoenzymes PD I and PD II. PD II activity is highest in the hippocampus, followed by the cerebellum, cerebral cortex, caudatum, and the midbrain. Age-related alterations in PD I and PD II | Rattus norvegicus | - |
| brain cortex | - |
Rattus norvegicus | - |
| caudatum | - |
Rattus norvegicus | - |
| cerebellum | - |
Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
| hypothalamus | - |
Rattus norvegicus | - |
| midbrain | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
overall tissue-specific prolidase activity in brain regions with different substrates | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Ala-Pro + H2O | best substrate of isozyme PD I | Rattus norvegicus | Ala + Pro | - |
? | |
| Gly-Pro + H2O | very low activity with isozyme PD II | Rattus norvegicus | Gly + Pro | - |
? | |
| Met-Pro + H2O | best substrate of isozyme PD II | Rattus norvegicus | Met + Pro | - |
? | |
| Phe-Pro + H2O | - |
Rattus norvegicus | Phe + Pro | - |
? | |
| Pro-Pro + H2O | substrate of isozyme PD II, negligible activity with isozyme PD I | Rattus norvegicus | Pro + Pro | - |
? | |
| Ser-Pro + H2O | best substrate of isozyme PD I | Rattus norvegicus | Ser + Pro | - |
? | |
| Val-Pro + H2O | - |
Rattus norvegicus | Val + Pro | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| prolidase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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