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Literature summary for 3.4.13.9 extracted from
- Doxycycline-induced inhibition of prolidase activity in human skin fibroblasts and its involvement in impaired collagen biosynthesis (2001), Eur. J. Pharmacol., 430, 25-31.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme is a possible target for doxycyclin-induced inhibition of collagen synthesis in the treatment of osteoarthritis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| doxycyclin | induces down-regulation of the enzyme as a post-translational event | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | dependent on | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme is involved in collagen metabolism, enzyme activity is regulated through the beta1 integrin receptor | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| hydrolysis of Xaa-/-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro | cleaves imidodipeptides containing C-terminal proline providing a large amount of proline for collagen resynthesis | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| chondrocyte | - |
Homo sapiens | - |
| skin fibroblast | cell culture | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-Pro + H2O | - |
Homo sapiens | Gly + Pro | - |
? | |
| additional information | the enzyme is involved in collagen metabolism, enzyme activity is regulated through the beta1 integrin receptor | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | enzyme belongs to the methionyl amino peptidase family M24, fomerly EC 3.4.3.7 | Homo sapiens |
| prolidase | exopeptidase | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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