Protein Variants | Comment | Organism |
---|---|---|
C102S | efficiency for carnosine degradation is not influenced by the addition of cysteine | Mus musculus |
C229S | addition of cysteine to C229S significantly reduces CN1 catalytic efficiency | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cysteine | lowers dose-dependently recombinant CN1 efficiency | Mus musculus | |
N-acetylcysteine | lowers dose-dependently recombinant CN1 efficiency | Mus musculus | |
reduced glutathione | lowers dose-dependently recombinant CN1 efficiency | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
carnosine | pH 7.0, temperature not specified in the publication, presence of 1 mM glycine | Mus musculus | |
0.8 | - |
carnosine | pH 7.0, temperature not specified in the publication | Mus musculus | |
0.8 | - |
carnosine | pH 7.0, temperature not specified in the publication, presence of 1 mM L-glutamate | Mus musculus | |
0.9 | - |
carnosine | pH 7.0, temperature not specified in the publication, presence of 1 mM glutathione | Mus musculus | |
0.9 | - |
carnosine | pH 7.0, temperature not specified in the publication, presence of 1 mM reduced glutathione | Mus musculus | |
1 | - |
carnosine | pH 7.0, temperature not specified in the publication, presence of 1 mM cysteine | Mus musculus | |
1.1 | - |
carnosine | pH 7.0, temperature not specified in the publication, presence of 1 mM N-acetylcysteine | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BUG2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
carnosine + H2O | - |
Mus musculus | beta-Ala + His | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CN1 | - |
Mus musculus |
CNDP1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | reduced glutathione, N-acetylcysteine and cysteine lower dose-dependently recombinant CN1 efficiency and normalize increased CN1 activity in renal tissue samples of diabetic mice. Inhibition is allosteric. Only cysteine-102 is influenced by cysteinylation | Mus musculus |