Cloned (Comment) | Organism |
---|---|
expression in CHO cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D166A | mutation in putative metal binding site, complete loss of activity | Homo sapiens |
E201A | mutation in putative metal binding site, complete loss of activity | Homo sapiens |
E201A/D229A | mutation in putative metal binding site, complete loss of activity | Homo sapiens |
H133A | mutation in putative metal binding site, complete loss of activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bestatin | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
homocarnosine | pH 7.5, 30°C | Homo sapiens | |
1.27 | - |
beta-Ala-L-His | pH 7.5, 30°C | Homo sapiens | |
1.9 | - |
homocarnosine | presence of CD2+, pH 7.5, 30°C | Homo sapiens | |
11 | - |
beta-Ala-L-His | presence of CD2+, pH 7.5, 30°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | increase in kcat value | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52800 | - |
2 * 82000, SDS-PAGE, 2 * 63700, MALDI-TOF, 2 * 52800, calculated | Homo sapiens |
63700 | - |
2 * 82000, SDS-PAGE, 2 * 63700, MALDI-TOF, 2 * 52800, calculated | Homo sapiens |
82000 | - |
2 * 82000, SDS-PAGE, 2 * 63700, MALDI-TOF, 2 * 52800, calculated | Homo sapiens |
167000 | - |
gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96KN2 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | after treatment with PNGase F, molecular mass shifts from 82000 Da to 62000 Da, SDS-PAGE | Homo sapiens |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | of adult. No expression in fetal brain | Homo sapiens | - |
central nervous system | - |
Homo sapiens | - |
liver | low expresion | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-Ala-L-His + H2O | - |
Homo sapiens | beta-Ala + L-His | - |
? | |
Gly-L-His + H2O | - |
Homo sapiens | Gly + L-His | - |
? | |
homocarnosine + H2O | - |
Homo sapiens | ? | - |
? | |
L-Ala-L-His + H2O | - |
Homo sapiens | L-Ala + L-His | - |
? | |
additional information | non Xaa-His dipeptides like Ala-Ala, or Ala-Pro, as well as tripeptides containing histidine in central or C-terminal position such as Gly-His-Gly or Gly-Gly-His, are not degraded | Homo sapiens | ? | - |
? | |
N-methylcarnosine + H2O | - |
Homo sapiens | N-methyl-beta-Ala + L-His | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 82000, SDS-PAGE, 2 * 63700, MALDI-TOF, 2 * 52800, calculated | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CN1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
homocarnosine | pH 7.5, 30°C | Homo sapiens | |
10.6 | - |
beta-Ala-L-His | pH 7.5, 30°C | Homo sapiens | |
18 | - |
homocarnosine | presence of CD2+, pH 7.5, 30°C | Homo sapiens | |
138 | - |
beta-Ala-L-His | presence of CD2+, pH 7.5, 30°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | broad | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000007 | - |
bestatin | pH 7.5, 30°C | Homo sapiens |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Homo sapiens | calculated | - |
4.5 |