Application | Comment | Organism |
---|---|---|
medicine | CNDP1 secretion is significantly higher in cells expressing variants with more than five leucines in the signal peptide of the protein. This explains why individuals homozygous for the 5L allele have low serum carnosinase activity and why diabetic patients homozygous for CNDP1 5L are protected against diabetic nephropathy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in COS-7 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of constructs varying in CTG repeats coding for 4,5,6,7,or 8 leucines in the signal peptide. Enzyme secretion is significantly higher in cells expressing variants with more than five leucins in the signal peptide | Homo sapiens |
additional information | transfection of Cos-7 cells with different gene constructs varying in CTG repeats. CNDP1 secretion is significantly higher in cells expressing variants with more than five leucines in the signal peptide of the protein. With increasing length of the CTG repeat, the percentage of secreted carnosinase increases | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
extracellular | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
86000 | - |
x* 92000, SDS-PAGE of secreted protein, x * 86000 and x * 88000, SDS-PAGE of cytosolic protein | Homo sapiens |
88000 | - |
x* 92000, SDS-PAGE of secreted protein, x * 86000 and x * 88000, SDS-PAGE of cytosolic protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
isoform CDNP1 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | secreted enzyme shows a molecular weight of 92000 Da, cytosolic protein of 86000 Da and 88000 Da, respectively. PNGase-treated protein has a molecular weight of 86000 Da | Homo sapiens |
Subunits | Comment | Organism |
---|---|---|
? | x* 92000, SDS-PAGE of secreted protein, x * 86000 and x * 88000, SDS-PAGE of cytosolic protein | Homo sapiens |