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Literature summary for 3.4.13.19 extracted from

  • Gabrilovac, J.; Cupic, B.; Zapletal, E.; Kraus, O.; Jakic-Razumovic, J.
    Dipeptidyl peptidase 9 (DPP9) in human skin cells (2017), Immunobiology, 222, 327-342 .
    View publication on PubMed
Search for more literature for 3.4.13.19

Inhibitors

Inhibitors Comment Organism Structure
1G244 i.e. (2S)-2-amino-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-1-(1,3-dihydro-2H-isoindol-2-yl)-1,4-butanedione, specific inhibitor of DPP8 and DPP9 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
Golgi apparatus low expression level Homo sapiens 5794
-
nucleus and perinucleus Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86TI2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast isolated from skin Homo sapiens
-
keratinocyte
-
 Homo sapiens
-
skin
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
DPP9
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function survival and the proliferative capacity are significantly diminished in the presence of 10 microM of inhibitor 1G244, both in fibroblasts and in HaCaT cells. DPP9 gene silencing results in decreased adhesion of fibroblasts, as well as in decreased migration of fibroblasts and HaCaTcells. DPP9 accumulates on the edges of plasma membranes of fibroblasts and keratinocytes adhering to surface Homo sapiens