Literature summary for 3.4.13.19 extracted from

Kohchi, Y.; Hattori, K.; Oikawa, N.; Mizuguchi, E.; Isshiki, Y.; Aso, K.; Yoshinari, K.; Shirai, H.; Miwa, M.; Inagaki, Y.; Ura, M.; Ogawa, K.; Okabe, H.; Ishitsuka, H.; Shimma, N.
Design and synthesis of novel prodrugs of 2-deoxy-2-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues (2007), Bioorg. Med. Chem. Lett., 17, 2241-2245.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-
additional information	not found in liver or hematopoietic progenitor cells such as colony-forming units of granulocyte-macrophage	Homo sapiens	-
stomach cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2R)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]-2-methylpropanoic acid + H2O	-	Homo sapiens	?	-	?
(2R,3S)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2R,3S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2R,3S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]-2-methylpropanoic acid + H2O	-	Homo sapiens	?	-	?
(2S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]propanoic acid + H2O	-	Homo sapiens	?	-	?
(2S,3S)-2-[[(2S)-2-amino-3-biphenyl-4-ylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2S,3S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]-4-methylpentanoic acid + H2O	-	Homo sapiens	?	-	?
(2S,3S)-2-[[(2S)-2-amino-3-cyclohexylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2S,3S)-2-[[(2S)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2S,3S)-2-[[(2S)-3-cyclohexyl-2-(dimethylamino)propanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2S,3S)-2-[[(2S)-3-cyclohexyl-2-(formylamino)propanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
(2S,3S)-2-[[(2S)-3-cyclohexyl-2-(methylamino)propanoyl]amino]-3-[([1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylidenetetrahydrofuran-2-yl]-2-oxo-1,2-dihydropyrimidin-4-yl]carbamoyl)oxy]butanoic acid + H2O	-	Homo sapiens	?	-	?
N-[([(1S,2R)-2-[(3-cyclohexyl-L-alanyl)amino]-3-hydroxy-1-methylpropyl]oxy)carbonyl]-2'-deoxy-2'-methylidenecytidine + H2O	-	Homo sapiens	?	-	?
N-[([(1S,2S)-2-[(3-cyclohexyl-L-alanyl)amino]-1,4-dimethyl-3-oxopentyl]oxy)carbonyl]-2'-deoxy-2'-methylidenecytidine + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
MBD	-	Homo sapiens

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Release 2023.1 (January 2023)