Literature summary for 3.4.13.19 extracted from

Gurulingappa, H.; Buckhalts, P.; Kinzler, K.W.; Vogelstein, B.; Khan, S.R.
Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase (2004), Bioorg. Med. Chem. Lett., 14, 3531-3533.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-(trifluoromethyl)phenyl)acrylic acid	50% inhibition at 10 nM	Homo sapiens
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-bromophenyl)acrylic acid	50% inhibition at 6 nM	Homo sapiens
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-fluorophenyl)acrylic acid	50% inhibition at 5 nM	Homo sapiens
(2Z)-2-[[(1-amino-2-cyclohexylethyl)(hydroxy)phosphoryl]methyl]-3-(4-iodophenyl)acrylic acid	50% inhibition at 8 nM	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colonic cancer cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)