Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells and 293-T cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
F822A | decreased activity | Homo sapiens |
H859A | decreased activity | Homo sapiens |
V833A | decreased activity | Homo sapiens |
Y844A | decreased activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
Lys-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
0.023 | - |
Leu-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
0.027 | - |
Arg-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
0.029 | - |
Met-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
0.127 | - |
Ala-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
0.238 | - |
Ser-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
0.27 | - |
Arg-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
0.325 | - |
Met-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
0.348 | - |
Leu-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
0.39 | - |
Leu-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.507 | - |
Lys-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
0.528 | - |
Gly-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
0.988 | - |
Met-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
1.358 | - |
Lys-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
1.495 | - |
Ala-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
1.673 | - |
Arg-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
2.219 | - |
Ala-Pro-p-nitroanilide | mutant enzyme V833A | Homo sapiens | |
2.249 | - |
Ser-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
2.397 | - |
Ala-Pro-p-nitroanilide | mutant enzyme Y844A | Homo sapiens | |
2.668 | - |
Asp-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
2.72 | - |
Ala-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
2.731 | - |
Gly-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
4.599 | - |
Gly-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
7.462 | - |
Ser-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
105000 | - |
2 * 105000, His-tagged enzyme, SDS-PAGE | Homo sapiens |
210000 | - |
His-tagged enzyme, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography, Q-Sepharose column chromatography, and Superdex 200 HR gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ala-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Ala-Pro + p-nitroaniline | - |
? | |
Arg-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Arg-Pro + p-nitroaniline | - |
? | |
Asp-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Asp-Pro + p-nitroaniline | - |
? | |
Gly-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Gly-Pro + p-nitroaniline | - |
? | |
Leu-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Leu-Pro + p-nitroaniline | - |
? | |
Lys-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Lys-Pro + p-nitroaniline | - |
? | |
Met-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Met-Pro + p-nitroaniline | - |
? | |
Ser-Pro-p-nitroanilide + H2O | - |
Homo sapiens | Ser-Pro + p-nitroaniline | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 105000, His-tagged enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
DPP8 | - |
Homo sapiens |
prolyl dipeptidase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
Ser-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.1 | - |
Leu-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.2 | - |
Gly-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.2 | - |
Ala-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.2 | - |
Lys-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.2 | - |
Ala-Pro-p-nitroanilide | mutant enzyme Y844A | Homo sapiens | |
0.3 | - |
Met-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.4 | - |
Arg-Pro-p-nitroanilide | mutant enzyme F822A | Homo sapiens | |
0.9 | - |
Asp-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
1 | - |
Ala-Pro-p-nitroanilide | mutant enzyme V833A | Homo sapiens | |
1.2 | - |
Arg-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
1.4 | - |
Gly-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
2.4 | - |
Lys-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
3 | - |
Met-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
3.2 | - |
Lys-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
3.8 | - |
Leu-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
7 | - |
Leu-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
8 | - |
Ala-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
13 | - |
Ser-Pro-p-nitroanilide | mutant enzyme H859A | Homo sapiens | |
14 | - |
Arg-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
15 | - |
Met-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
19 | - |
Ser-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
22 | - |
Ala-Pro-p-nitroanilide | wild type enzyme | Homo sapiens | |
25 | - |
Gly-Pro-p-nitroanilide | wild type enzyme | Homo sapiens |