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Literature summary for 3.4.11.7 extracted from

  • Bodineau, L.; Frugiere, A.; Marc, Y.; Claperon, C.; Llorens-Cortes, C.
    Aminopeptidase A inhibitors as centrally acting antihypertensive agents (2008), Heart Fail. Rev., 13, 311-319.
    View publication on PubMed

Application

Application Comment Organism
medicine central APA is a potential therapeutic target for the treatment of hypertension Mus musculus
medicine central APA is a potential therapeutic target for the treatment of hypertension Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(S)-3-amino-4-mercaptobutyl sulfonic acid EC33, specific and selective APA inhibitor Mus musculus
(S)-3-amino-4-mercaptobutyl sulfonic acid EC33, specific and selective APA inhibitor Rattus norvegicus
4,4'-dithio[bis(3)-aminobutylsulfonic acid] RB150, a prodrug of EC33 Rattus norvegicus
4,4'-dithio[bis(3-aminobutyl sulfonic acid)] RB150, a prodrug of EC33 Mus musculus
amastatin inhibits APA and APN Mus musculus
amastatin inhibits APA and APN Rattus norvegicus
bestatin broad specificity for various aminopeptidases Mus musculus
bestatin broad specificity for various aminopeptidases Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Mus musculus
Zn2+
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
120000
-
monomer Mus musculus
120000
-
monomer Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
brain
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Mus musculus aspartic acid + angiotensin III angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe ?
angiotensin II + H2O angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe Rattus norvegicus aspartic acid + angiotensin III angiotensin III: Arg-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe ?

Synonyms

Synonyms Comment Organism
aminopeptidase A
-
Mus musculus
aminopeptidase A
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00025
-
(S)-3-amino-4-mercaptobutyl sulfonic acid
-
Rattus norvegicus
0.00025
-
[(S)-3-amino-4-mercaptobutyl sulfonic acid]
-
Mus musculus