Application | Comment | Organism |
---|---|---|
medicine | central APA is a potential therapeutic target for the treatment of hypertension | Mus musculus |
medicine | central APA is a potential therapeutic target for the treatment of hypertension | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-3-amino-4-mercaptobutyl sulfonic acid | EC33, specific and selective APA inhibitor | Mus musculus | |
(S)-3-amino-4-mercaptobutyl sulfonic acid | EC33, specific and selective APA inhibitor | Rattus norvegicus | |
4,4'-dithio[bis(3)-aminobutylsulfonic acid] | RB150, a prodrug of EC33 | Rattus norvegicus | |
4,4'-dithio[bis(3-aminobutyl sulfonic acid)] | RB150, a prodrug of EC33 | Mus musculus | |
amastatin | inhibits APA and APN | Mus musculus | |
amastatin | inhibits APA and APN | Rattus norvegicus | |
bestatin | broad specificity for various aminopeptidases | Mus musculus | |
bestatin | broad specificity for various aminopeptidases | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Mus musculus | |
Zn2+ | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
120000 | - |
monomer | Mus musculus |
120000 | - |
monomer | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
angiotensin II + H2O | angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | Mus musculus | aspartic acid + angiotensin III | angiotensin III: Arg-Val-Tyr-Ile-His-Pro-Phe | ? | |
angiotensin II + H2O | angiotensin II: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | Rattus norvegicus | aspartic acid + angiotensin III | angiotensin III: Arg-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | ? |
Synonyms | Comment | Organism |
---|---|---|
aminopeptidase A | - |
Mus musculus |
aminopeptidase A | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00025 | - |
(S)-3-amino-4-mercaptobutyl sulfonic acid | - |
Rattus norvegicus | |
0.00025 | - |
[(S)-3-amino-4-mercaptobutyl sulfonic acid] | - |
Mus musculus |