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Literature summary for 3.4.11.7 extracted from
- Glutamyl aminopeptidase (Lactococcus) (2004), Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds) Academic Press, 2nd. Ed. 1, 965-968.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Lactococcus lactis |  |
| EDTA | - |
Leuconostoc mesenteroides | |
| EDTA | - |
Streptococcus agalactiae | |
| EDTA | - |
Streptococcus mutans | |
| EDTA | - |
Streptococcus pneumoniae | |
| EDTA | - |
Streptococcus pyogenes | |
| EDTA | - |
Streptococcus suis | |
| Zn2+ | - |
Lactococcus lactis | |
| Zn2+ | - |
Leuconostoc mesenteroides | |
| Zn2+ | - |
Streptococcus agalactiae | |
| Zn2+ | - |
Streptococcus mutans | |
| Zn2+ | - |
Streptococcus pneumoniae | |
| Zn2+ | - |
Streptococcus pyogenes | |
| Zn2+ | - |
Streptococcus suis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.21 | - |
Asp-Ala | - |
Lactococcus lactis | |
| 0.28 | - |
Glu-Ala | - |
Lactococcus lactis | |
| 27.3 | - |
Ser-Ala | - |
Lactococcus lactis | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | possibly membrane-associated at the cell surface | Lactococcus lactis | - |
- |
| additional information | possibly membrane-associated at the cell surface | Streptococcus pneumoniae | - |
- |
| additional information | possibly membrane-associated at the cell surface | Streptococcus pyogenes | - |
- |
| additional information | possibly membrane-associated at the cell surface | Leuconostoc mesenteroides | - |
- |
| additional information | possibly membrane-associated at the cell surface | Streptococcus agalactiae | - |
- |
| additional information | possibly membrane-associated at the cell surface | Streptococcus mutans | - |
- |
| additional information | possibly membrane-associated at the cell surface | Streptococcus suis | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | activates | Lactococcus lactis | |
| Co2+ | activates | Streptococcus pneumoniae | |
| Co2+ | activates | Streptococcus pyogenes | |
| Co2+ | activates | Leuconostoc mesenteroides | |
| Co2+ | activates | Streptococcus agalactiae | |
| Co2+ | activates | Streptococcus mutans | |
| Co2+ | activates | Streptococcus suis | |
| additional information | metallopeptidase | Lactococcus lactis | |
| additional information | metallopeptidase | Streptococcus pneumoniae | |
| additional information | metallopeptidase | Streptococcus pyogenes | |
| additional information | metallopeptidase | Leuconostoc mesenteroides | |
| additional information | metallopeptidase | Streptococcus agalactiae | |
| additional information | metallopeptidase | Streptococcus mutans | |
| additional information | metallopeptidase | Streptococcus suis |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Lactococcus lactis |
| additional information | - |
- |
Streptococcus pneumoniae |
| additional information | - |
- |
Streptococcus pyogenes |
| additional information | - |
- |
Leuconostoc mesenteroides |
| additional information | - |
- |
Streptococcus agalactiae |
| additional information | - |
- |
Streptococcus mutans |
| additional information | - |
- |
Streptococcus suis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Lactococcus lactis | potential biological functions, overview | ? | - |
? | |
| additional information | Streptococcus pneumoniae | potential biological functions, overview | ? | - |
? | |
| additional information | Streptococcus pyogenes | potential biological functions, overview | ? | - |
? | |
| additional information | Leuconostoc mesenteroides | potential biological functions, overview | ? | - |
? | |
| additional information | Streptococcus agalactiae | potential biological functions, overview | ? | - |
? | |
| additional information | Streptococcus mutans | potential biological functions, overview | ? | - |
? | |
| additional information | Streptococcus suis | potential biological functions, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactococcus lactis | - |
ssp. cremoris, formerly Streptococcus cremoris | - |
| Leuconostoc mesenteroides | - |
- |
- |
| Streptococcus agalactiae | - |
- |
- |
| Streptococcus mutans | - |
- |
- |
| Streptococcus pneumoniae | - |
- |
- |
| Streptococcus pyogenes | - |
- |
- |
| Streptococcus suis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native enzyme 634fold and 144fold from strain NCDO 607, 727fold from strain NCDO 712, and 387fold from strain NCDO1968 | Lactococcus lactis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Asp-Ala + H2O | 74% of the activity with Glu-Ala | Lactococcus lactis | Asp + Ala | - |
? | |
| Glu-Ala + H2O | high activity | Lactococcus lactis | Glu + Ala | - |
? | |
| additional information | potential biological functions, overview | Lactococcus lactis | ? | - |
? | |
| additional information | potential biological functions, overview | Streptococcus pneumoniae | ? | - |
? | |
| additional information | potential biological functions, overview | Streptococcus pyogenes | ? | - |
? | |
| additional information | potential biological functions, overview | Leuconostoc mesenteroides | ? | - |
? | |
| additional information | potential biological functions, overview | Streptococcus agalactiae | ? | - |
? | |
| additional information | potential biological functions, overview | Streptococcus mutans | ? | - |
? | |
| additional information | potential biological functions, overview | Streptococcus suis | ? | - |
? | |
| additional information | the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates | Streptococcus pneumoniae | ? | - |
? | |
| additional information | the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates | Streptococcus pyogenes | ? | - |
? | |
| additional information | the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates | Leuconostoc mesenteroides | ? | - |
? | |
| additional information | the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates | Streptococcus agalactiae | ? | - |
? | |
| additional information | the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates | Streptococcus mutans | ? | - |
? | |
| additional information | the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates | Streptococcus suis | ? | - |
? | |
| additional information | the enzyme removes N-terminal Glu, Asp, and to a lesser extent also Ser residues from peptide substrates, no activity with Glu-substrate with a blocked N-terminus | Lactococcus lactis | ? | - |
? | |
| Ser-Ala + H2O | less than 2% of the activity with Glu-Ala | Lactococcus lactis | Ser + Ala | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aminopeptidase A | - |
Lactococcus lactis |
| GAP | - |
Lactococcus lactis |
| glutamyl aminopeptidase (Lactococcus) | - |
Lactococcus lactis |
| glutamyl aminopeptidase (Lactococcus) | - |
Streptococcus pneumoniae |
| glutamyl aminopeptidase (Lactococcus) | - |
Streptococcus pyogenes |
| glutamyl aminopeptidase (Lactococcus) | - |
Leuconostoc mesenteroides |
| glutamyl aminopeptidase (Lactococcus) | - |
Streptococcus agalactiae |
| glutamyl aminopeptidase (Lactococcus) | - |
Streptococcus mutans |
| glutamyl aminopeptidase (Lactococcus) | - |
Streptococcus suis |
| More | the enzyme belongs to peptidase family M42 | Lactococcus lactis |
| More | the enzyme belongs to peptidase family M42 | Streptococcus pneumoniae |
| More | the enzyme belongs to peptidase family M42 | Streptococcus pyogenes |
| More | the enzyme belongs to peptidase family M42 | Leuconostoc mesenteroides |
| More | the enzyme belongs to peptidase family M42 | Streptococcus agalactiae |
| More | the enzyme belongs to peptidase family M42 | Streptococcus mutans |
| More | the enzyme belongs to peptidase family M42 | Streptococcus suis |
| PepA | - |
Lactococcus lactis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | 65 | - |
Lactococcus lactis |
| 50 | 65 | - |
Streptococcus pneumoniae |
| 50 | 65 | - |
Streptococcus pyogenes |
| 50 | 65 | - |
Leuconostoc mesenteroides |
| 50 | 65 | - |
Streptococcus agalactiae |
| 50 | 65 | - |
Streptococcus mutans |
| 50 | 65 | - |
Streptococcus suis |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
120 min, purified enzyme, stable | Lactococcus lactis |
| 70 | - |
60 min, purified enzyme, stable, 54% remaining activity after 120 min | Lactococcus lactis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
approximately | Lactococcus lactis |
| 8 | - |
approximately | Streptococcus pneumoniae |
| 8 | - |
approximately | Streptococcus pyogenes |
| 8 | - |
approximately | Leuconostoc mesenteroides |
| 8 | - |
approximately | Streptococcus agalactiae |
| 8 | - |
approximately | Streptococcus mutans |
| 8 | - |
approximately | Streptococcus suis |
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