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Literature summary for 3.4.11.7 extracted from
- Aminopeptidase A (2004), Handbook of Proteolytic Enzymes (2nd Edition), 1, 299-303.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| BP-1/6C3 antigen, gene ENPEP, full-length DNA and amino acid sequence determination and analysis, genetic structure, determination of 5'-flanking regions, promoter sequence, and DNA-binding motifs for transcription factors, overview, transient or stable expression of recombinant enzyme with transmembrane regions or cytoplasmic regions by human interleukin 4 leader sequence in COS-7 cells | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Mus musculus |  |
| Cd2+ | complete inhibition at 1 mM | Mus musculus | |
| Cu2+ | complete inhibition at 1 mM | Mus musculus | |
| EC33 | specific inhibition | Mus musculus | |
| EDTA | - |
Mus musculus | |
| EGTA | - |
Mus musculus | |
| Hg2+ | complete inhibition at 1 mM | Mus musculus | |
| Ni2+ | complete inhibition at 1 mM | Mus musculus | |
| RB150 | selective and specific prodrug of the enzyme inhibitor EC33, inhibits the enzyme given i.v. to rats | Mus musculus | |
| Zn2+ | complete inhibition at 1 mM | Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | the enzyme has cytosolic and transmembrane regions | Mus musculus | 5737 | - |
| membrane | the enzyme has cytosolic and transmembrane regions | Mus musculus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | 400000 | dependent on the tissue source and purification method | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is involved in angiotensin metabolism | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P16406 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant enzyme from COS-7 cells by BP-1 antibody affinity chromatography | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| enterocyte | intestinal, brush border | Mus musculus | - |
| hypothalamus | - |
Mus musculus | - |
| kidney | brush border | Mus musculus | - |
| additional information | broad tissue distribution | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in angiotensin metabolism | Mus musculus | ? | - |
? | |
| additional information | the enzyme catalyzes the hydrolysis of N-(alpha-L-glutamyl)- moieties more efficiently than the hydrolysis of alpha-L-aspartyl derivatives | Mus musculus | ? | - |
? | |
| N-(alpha-L-glutamyl)-4-nitroanilide + H2O | - |
Mus musculus | L-glutamic acid + 4-nitroaniline | - |
? | |
| N-(alpha-L-glutamyl)-beta-naphthylamide + H2O | - |
Mus musculus | L-glutamic acid + beta-naphthylamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acidic alpha-aminopeptidase | - |
Mus musculus |
| aminopeptidase A | - |
Mus musculus |
| angiotensinase A | - |
Mus musculus |
| APA | - |
Mus musculus |
| aspartate aminopeptidase | - |
Mus musculus |
| BP-1/6C3 antigen | - |
Mus musculus |
| Ca2+-activated glutamate aminopeptidase | - |
Mus musculus |
| EAP | - |
Mus musculus |
| glutamyl aminopeptidase | - |
Mus musculus |
| membrane aminopeptidase II | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
approximately | Mus musculus |
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