Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Rattus norvegicus |
expressed in Escherichia coli | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arphamenine A | complete inhibition at 0.1 mM | Bos taurus | |
arphamenine A | complete inhibition at 0.1 mM | Rattus norvegicus | |
bestatin | complete inhibition at 0.1 mM | Bos taurus | |
bestatin | complete inhibition at 0.1 mM | Rattus norvegicus | |
beta-mercaptoethanol | 4% inhibition at 10 mM | Bos taurus | |
beta-mercaptoethanol | 20% inhibition at 10 mM | Rattus norvegicus | |
Co2+ | 62% inhibition at 1 mM | Bos taurus | |
Co2+ | 45% inhibition at 1 mM | Rattus norvegicus | |
cysteine | 21% inhibition at 1 mM | Bos taurus | |
cysteine | 15% inhibition at 1 mM | Rattus norvegicus | |
dithiothreitol | 33% inhibition at 10 mM | Bos taurus | |
dithiothreitol | 54% inhibition at 10 mM | Rattus norvegicus | |
E64 | 48% inhibition at 0.01 mM | Bos taurus | |
E64 | 12% inhibition at 0.01 mM | Rattus norvegicus | |
EDTA | 12% inhibition at 1 mM | Bos taurus | |
EDTA | 54% inhibition at 1 mM | Rattus norvegicus | |
N-ethylmaleimide | 44% inhibition at 0.1 mM | Bos taurus | |
N-ethylmaleimide | 21% inhibition at 0.1 mM | Rattus norvegicus | |
Ni2+ | 75% inhibition at 1 mM | Bos taurus | |
Ni2+ | 63% inhibition at 1 mM | Rattus norvegicus | |
Phenylmethanesulfonylfluoride | 10% inhibition at 0.1 mM | Bos taurus | |
Phenylmethanesulfonylfluoride | 1% inhibition at 0.1 mM | Rattus norvegicus | |
puromycin | 10% inhibition at 0.1 mM | Bos taurus | |
puromycin | 1% inhibition at 0.1 mM | Rattus norvegicus | |
Zn2+ | complete inhibition at 0.1 mM | Bos taurus | |
Zn2+ | 99% inhibition at 0.1 mM | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.048 | - |
L-Arg-7-amido-4-methylcoumarin | - |
Rattus norvegicus | |
0.091 | - |
L-Arg-7-amido-4-methylcoumarin | - |
Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
secretory vesicle | present in secretory vesicles that contain cathepsin L with the neuropeptides enkephalin and neuropeptide Y | Rattus norvegicus | 99503 | - |
secretory vesicle | present in secretory vesicles that contain cathepsin L with the neuropeptides enkephalin and neuropeptide Y | Bos taurus | 99503 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Na+ | 110% increase of activity at 150 mM | Rattus norvegicus | |
Na+ | 380% increase of activity at 150 mM | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72100 | - |
calculated from amino acid sequence | Bos taurus |
74000 | - |
SDS-PAGE | Rattus norvegicus |
74000 | - |
SDS-PAGE | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | A2T1U6 | - |
- |
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal medulla | - |
Rattus norvegicus | - |
adrenal medulla | - |
Bos taurus | - |
brain | - |
Rattus norvegicus | - |
hypothalamus | - |
Rattus norvegicus | - |
pancreas | - |
Rattus norvegicus | - |
pituitary gland | - |
Rattus norvegicus | - |
pituitary gland | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Arg-(Met)enkephalin + H2O | - |
Rattus norvegicus | L-Arg + (Met)enkephalin | - |
? | |
L-Arg-(Met)enkephalin + H2O | - |
Bos taurus | L-Arg + (Met)enkephalin | - |
? | |
L-Arg-7-amido-4-methylcoumarin + H2O | 100% activity | Rattus norvegicus | L-Arg + 7-amino-4-methylcoumarin | - |
? | |
L-Arg-7-amido-4-methylcoumarin + H2O | 100% activity | Bos taurus | L-Arg + 7-amino-4-methylcoumarin | - |
? | |
L-Asn-7-amido-4-methylcoumarin + H2O | 53% activity compared to L-Arg-7-amido-4-methylcoumarin | Bos taurus | L-Asn + 7-amino-4-methylcoumarin | - |
? | |
L-Asp-7-amido-4-methylcoumarin + H2O | 15% activity compared to L-Arg-7-amido-4-methylcoumarin | Bos taurus | L-Asp + 7-amino-4-methylcoumarin | - |
? | |
L-Cys-7-amido-4-methylcoumarin + H2O | 5% activity compared to L-Arg-7-amido-4-methylcoumarin | Rattus norvegicus | L-Cys + 7-amino-4-methylcoumarin | - |
? | |
L-Leu-7-amido-4-methylcoumarin + H2O | 28% activity compared to L-Arg-7-amido-4-methylcoumarin | Bos taurus | L-Leu + 7-amino-4-methylcoumarin | - |
? | |
L-Lys-(Met)enkephalin + H2O | - |
Rattus norvegicus | L-Lys + (Met)enkephalin | - |
? | |
L-Lys-(Met)enkephalin + H2O | - |
Bos taurus | L-Lys + (Met)enkephalin | - |
? | |
L-Lys-7-amido-4-methylcoumarin + H2O | 10% activity compared to L-Arg-7-amido-4-methylcoumarin | Bos taurus | L-Lys + 7-amino-4-methylcoumarin | - |
? | |
L-Lys-7-amido-4-methylcoumarin + H2O | 17% activity compared to L-Arg-7-amido-4-methylcoumarin | Rattus norvegicus | L-Lys + 7-amino-4-methylcoumarin | - |
? | |
L-Met-7-amido-4-methylcoumarin + H2O | 19% activity compared to L-Arg-7-amido-4-methylcoumarin | Bos taurus | L-Met + 7-amino-4-methylcoumarin | - |
? | |
L-Phe-7-amido-4-methylcoumarin + H2O | 2% activity compared to L-Arg-7-amido-4-methylcoumarin | Rattus norvegicus | L-Phe + 7-amino-4-methylcoumarin | - |
? | |
L-Pro-7-amido-4-methylcoumarin + H2O | 7% activity compared to L-Arg-7-amido-4-methylcoumarin | Rattus norvegicus | L-Pro + 7-amino-4-methylcoumarin | - |
? | |
L-Ser-7-amido-4-methylcoumarin + H2O | 15% activity compared to L-Arg-7-amido-4-methylcoumarin | Bos taurus | L-Ser + 7-amino-4-methylcoumarin | - |
? | |
additional information | no activity with L-Ala-7-amido-4-methylcoumarin, L-Asn-7-amido-4-methylcoumarin, L-Gln-7-amido-4-methylcoumarin, L-Glu-7-amido-4-methylcoumarin, Gly-7-amido-4-methylcoumarin, L-His-7-amido-4-methylcoumarin, L-Ile-7-amido-4-methylcoumarin, L-Leu-7-amido-4-methylcoumarin, L-Asp-7-amido-4-methylcoumarin, L-Thr-7-amido-4-methylcoumarin, L-Met-7-amido-4-methylcoumarin, L-Trp-7-amido-4-methylcoumarin, L-Ser-7-amido-4-methylcoumarin, L-Tyr-7-amido-4-methylcoumarin, and L-Val-7-amido-4-methylcoumarin | Rattus norvegicus | ? | - |
? | |
additional information | no activity with L-Ala-7-amido-4-methylcoumarin, L-Cys-7-amido-4-methylcoumarin, L-Gln-7-amido-4-methylcoumarin, L-Glu-7-amido-4-methylcoumarin, Gly-7-amido-4-methylcoumarin, L-His-7-amido-4-methylcoumarin, L-Ile-7-amido-4-methylcoumarin, L-Phe-7-amido-4-methylcoumarin, L-Pro-7-amido-4-methylcoumarin, L-Thr-7-amido-4-methylcoumarin, L-Trp-7-amido-4-methylcoumarin, L-Tyr-7-amido-4-methylcoumarin, and L-Val-7-amido-4-methylcoumarin | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ap-B | - |
Rattus norvegicus |
Ap-B | - |
Bos taurus |
Arg/Lys aminopeptidase | - |
Rattus norvegicus |
Arg/Lys aminopeptidase | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 6.5 | - |
Rattus norvegicus |
5.5 | 6.5 | - |
Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 7 | - |
Rattus norvegicus |
5 | 7 | - |
Bos taurus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Bos taurus | calculated from amino acid sequence | - |
5.3 |