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Literature summary for 3.4.11.4 extracted from

  • Ito, K.; Nakajima, Y.; Xu, Y.; Yamada, N.; Onohara, Y.; Ito, T.; Matsubara, F.; Kabashima, T.; Nakayama, K.; Yoshimoto, T.
    Crystal structure and mechanism of tripeptidyl activity of prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis (2006), J. Mol. Biol., 362, 228-240.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain M15 Porphyromonas gingivalis

Protein Variants

Protein Variants Comment Organism
S603A inactive Porphyromonas gingivalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.42
-
Gly-Ala-Pro-beta-naphthylamide in 20 mM Tris-HCl buffer (pH 7.0), at 37°C Serratia marcescens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
77000
-
2 * 77000, SDS-PAGE Porphyromonas gingivalis
145000
-
gel filtration Porphyromonas gingivalis
154000
-
SDS-PAGE Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Serratia marcescens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Toyopearl HW65C column chromatography and DEAE-Toyopearl column chromatography Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ala-Phe-Pro-beta-naphthylamide + H2O
-
Serratia marcescens Ala-Phe-Pro + beta-naphthylamine
-
?
Ala-Phe-Pro-beta-naphthylamide + H2O
-
Porphyromonas gingivalis Ala-Phe-Pro + beta-naphthylamine
-
?
Gly-Ala-Pro-beta-naphthylamide + H2O
-
Serratia marcescens Gly-Ala-Pro + beta-naphthylamine
-
?
additional information no activity with Gly-Pro-beta-naphthylamide, Z-Gly-Pro-beta-naphthylamide, Z-Gly-Ala-Pro-beta-naphthylamide, Z-Ala-Gly-Pro-beta-naphthylamide, Gly-Ala-Gly-Pro-beta-naphthylamide, Z-Gly-Ala-Gly-Pro-beta-naphthylamide, and Ala-Gly-Ala-Gly-Pro-beta-naphthylamide Serratia marcescens ?
-
?

Subunits

Subunits Comment Organism
homodimer 2 * 77000, SDS-PAGE Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
prolyl tripeptidyl aminopeptidase
-
Serratia marcescens
prolyl tripeptidyl aminopeptidase
-
Porphyromonas gingivalis
PTP
-
Serratia marcescens
PTP
-
Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
42
-
-
Serratia marcescens
42
-
-
Porphyromonas gingivalis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
354
-
Gly-Ala-Pro-beta-naphthylamide in 20 mM Tris-HCl buffer (pH 7.0), at 37°C Serratia marcescens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
Serratia marcescens
7.2
-
-
Porphyromonas gingivalis