Literature summary for 3.4.11.3 extracted from

Shibata, K.; Kajiyama, H.; Ino, K.; Nawa, A.; Nomura, S.; Mizutani, S.; Kikkawa, F.
P-LAP/IRAP-induced cell proliferation and glucose uptake in endometrial carcinoma cells via insulin receptor signaling (2007), BMC Cancer, 7, 15.

Search for more literature for 3.4.11.3

Application

Application	Comment	Organism
medicine	enzyme isoform IRAP is involved in increasing malignant potential of endometrial cancer mediated by insulin. Endometrial adenocarcinoma A-MEC cells expressing the enzyme exhibit a significant growth-stimulatory effect compared with control. They have a remarkably high level of p85PI3K protein and show a higher degree of AKT phosphorylation by insulin stimulation	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in A-MEC cell	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	endometrial adenocarcinoma A-MEC cells expressing the enzyme exhibit a significant growth-stimulatory effect compared with control. They have a remarkably high level of p85PI3K protein and show a higher degree of AKT phosphorylation by insulin stimulation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

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Release 2023.1 (January 2023)