Literature summary for 3.4.11.22 extracted from

Xu, S.; Liu, H.W.; Hu, X.X.; Huan, S.Y.; Zhang, J.; Liu, Y.C.; Yuan, L.; Qu, F.L.; Zhang, X.B.; Tan, W.
Visualization of endoplasmic reticulum aminopeptidase 1 under different redox conditions with a two-photon fluorescent probe (2017), Anal. Chem., 89, 7641-7648 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
interferon gamma	treating HeLa cells with interferon-gamma increases the amount of ERAP1	Homo sapiens

Application

Application	Comment	Organism
analysis	two-photon fluorescent probe SNCL exhibits high sensitivity toward ERAP1, with about a 95-fold fluorescence enhancement at 550 nm. SNCL can be applied for monitoring ERAP1 in tumor tissue with an imaging depth of 50-120 microm	Homo sapiens
medicine	two-photon fluorescent probe SNCL exhibits high sensitivity toward ERAP1, with about a 95-fold fluorescence enhancement at 550 nm. SNCL can be applied for monitoring ERAP1 in tumor tissue with an imaging depth of 50-120 microm	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endoplasmic reticulum	the content of ERAP1 is dependent on the redox state of the endoplasmic reticulum	Homo sapiens	5783	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NZ08	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HeLa cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-(2-[(4-methylbenzene-1-sulfonyl)amino]ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-6-yl 2-[(leucylamino)methyl]piperidine-1-carboxylate + H2O	two-photon fluorescent probe SNCL, can be applied for monitoring of the activity in living cells and tissues	Homo sapiens	N-[2-(6-hydroxy-1,3-dioxo-6,6a-dihydro-1H-benzo[de]isoquinolin-2(3H)-yl)ethyl]-4-methylbenzene-1-sulfonamide + hexahydroimidazo[1,5-a]pyridin-3(2H)-one + 2-amino-4-methylpentanoic acid	-	?

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Release 2023.1 (January 2023)