Literature summary for 3.4.11.22 extracted from

Giastas, P.; Neu, M.; Rowland, P.; Stratikos, E.
High-resolution crystal structure of endoplasmic reticulum aminopeptidase 1 with bound phosphinic transition-state analogue inhibitor (2019), ACS Med. Chem. Lett., 10, 708-713 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
to 1.6 A resolution, structure of the closed-conformation of ERAP1 with inhibitor Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide bound in its active site. Inhibitor Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide is coordinated to the zinc ion via its phosphinic group with a geometry that imitates a transition state analogue	Homo sapiens

Crystallization (Comment)

Organism

to 1.6 A resolution, structure of the closed-conformation of ERAP1 with inhibitor Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide bound in its active site. Inhibitor Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide is coordinated to the zinc ion via its phosphinic group with a geometry that imitates a transition state analogue

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Nalpha-(2-[[(1-amino-3-phenylpropyl)(hydroxy)phosphoryl]methyl]pent-4-ynoyl)-D-phenylalaninamide	potent phosphinic pseudopeptide inhibitor	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NZ08	isoform ERAP1	-

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Release 2023.1 (January 2023)