Literature summary for 3.4.11.22 extracted from

Andrei-Selmer, C.; Knuppel, A.; Satyanarayana, C.; Heese, C.; Schu, P.V.
A new class of mutants deficient in dodecamerization of aminopeptidase 1 and vacuolar transport (2001), J. Biol. Chem., 276, 11606-11614.

Search for more literature for 3.4.11.22

Cloned(Commentary)

Cloned (Comment)	Organism
gene APE1, DNA and amino acid sequence determination and analysis, single copy gene, expression of wild-type and mutant precursor enzymes in yeast	Saccharomyces cerevisiae

Protein Variants

Protein Variants	Comment	Organism
additional information	isolation and/or construction of mutant enzymes defective in autophagocytosis and vacuole biogenesis, the mutant enzyme accumulates in the Cvt vesicles of the secretory pathway in non-native conformation, overview	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	precursor protein of the enzyme	Saccharomyces cerevisiae	5829	-
vacuole	the precursor enzyme is transported into the vacuole via the non-classic Cvt pathway by cytoplasmic double-membrane vesicles, which fuse with the vacuole releasing a single-membrane autophagic body into the vacuolar lumen where it is proteolytically maturated, overview	Saccharomyces cerevisiae	5773	-

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	maturation of the cytosolic precursor protein to the mature enzyme in the vacuolar lumen	Saccharomyces cerevisiae

Purification (Commentary)

Purification (Comment)	Organism
recombinant wild-type and mutant precursor enzymes	Saccharomyces cerevisiae

Subunits

Subunits	Comment	Organism
dodecamer	homododecamer	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
aminopeptidase 1	-	Saccharomyces cerevisiae
APE1	-	Saccharomyces cerevisiae
pApe1p	-	Saccharomyces cerevisiae
vacuolar aminopeptidase 1	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)